ArticleVaccine2010
A lyophilized formulation of RiVax, a recombinant ricin subunit vaccine, retains immunogenicity.
Article in Vaccine, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 33 citations in OpenAlex.
- Randomized-field microwave-assisted pharmaceutical lyophilization with closed-loop control.Scientific reports · 2025Article
- Respiratory delivered vaccines: Current status and perspectives in rational formulation design.Acta pharmaceutica Sinica. B · 2024Review
- Durable Immunity to Ricin Toxin Elicited by a Thermostable, Lyophilized Subunit Vaccine.mSphere · 2021Article
- Article
- Enhancing Efficacy and Stability of an Antiheroin Vaccine: Examination of Antinociception, Opioid Binding Profile, and Lethality.Molecular pharmaceutics · 2018Article
- Rational design of heat stable lyophilized rotavirus vaccine formulations.Human vaccines & immunotherapeutics · 2018Article
- Enhancement of humoral immunity by the type II heat-labile enterotoxin LT-IIb is dependent upon IL-6 and neutrophils.Journal of leukocyte biology · 2016Article
- Isolation of Anti-Ricin Protective Antibodies Exhibiting High Affinity from Immunized Non-Human Primates.Toxins · 2016Article
- Thermostable ricin vaccine protects rhesus macaques against aerosolized ricin: Epitope-specific neutralizing antibodies correlate with protection.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- A recombinant chimeric protein containing B chains of ricin and abrin is an effective vaccine candidate.Human vaccines & immunotherapeutics · 2014Article
- Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization.European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V · 2013Article
- Article
- The need for continued development of ricin countermeasures.Advances in preventive medicine · 2012Article
- Ricinus communis intoxications in human and veterinary medicine-a summary of real cases.Toxins · 2011Review
- Plant ribosome-inactivating proteins type II induce the unfolded protein response in human cancer cells.Cellular and molecular life sciences : CMLS · 2011Article
- Modulation of toxin stability by 4-phenylbutyric acid and negatively charged phospholipids.PloS one · 2011Article
- Intradermal administration of RiVax protects mice from mucosal and systemic ricin intoxication.Vaccine · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Ricin is a CDC level B biothreat. Our recombinant ricin A chain vaccine (RiVax) contains two mutations, rendering it non-toxic at high doses. Frozen or alum formulations of RiVax protected mice against ricin administered by injection, gavage or aerosol. Without alum, RiVax was safe and immunogenic in rabbits and human volunteers. For military use, the predominant target group, it would be optimal not to require a cold chain for transport and storage. We have now developed a lyophilized formulation and demonstrated stability and efficacy for at least 1 year stored refrigerated or at room temperature administered with or without alum.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.