ArticleHuman immunology2010
APOE polymorphism and its effect on plasma C-reactive protein levels in a large general population sample.
Article in Human immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 87 citations in OpenAlex.
- Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.Aging cell · 2011Pooled it
- Trial
- Stools from a human APOEe2 donor reduces amyloid and tau pathology and increases neuroinflammation in a 3xTg AD mouse model.Frontiers in aging neuroscience · 2025Article
- The mediating role of systemic inflammation and moderating role of racialization in disparities in incident dementia.Communications medicine · 2024Article
- Lipoprotein glomerulopathy with markedly increased arterial stiffness successfully treated with a combination of fenofibrate and losartan: a case report.BMC nephrology · 2024Article
- Statin use moderates APOE's and CRP's associations with dementia and is associated with lesser dementia severity in ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Identification of circulating proteins associated with general cognitive function among middle-aged and older adults.Communications biology · 2023Article
- Socio-Demographic, Lifestyle, and Cardiometabolic Characteristics Associated with Low-Grade Systemic Inflammation in Russian Adult Population.Biomolecules · 2023Article
- The Mediating Role of Systemic Inflammation and Moderating Role of Race/Ethnicity in Racialized Disparities in Incident Dementia: A Decomposition Analysis.Research square · 2023Article
- The Mediating Role of Systemic Inflammation and Moderating Role of Race/Ethnicity in Racialized Disparities in Incident Dementia: A Decomposition Analysis.medRxiv : the preprint server for health sciences · 2023Article
- Impact of hs-CRP concentration on brain structure alterations and cognitive trajectory in Alzheimer's disease.Frontiers in aging neuroscience · 2023Article
- Article
- Genetic pleiotropy underpinning adiposity and inflammation in self-identified Hispanic/Latino populations.BMC medical genomics · 2022Article
- Periodontitis as a Risk Factor for Alzheimer's Disease: The Experimental Journey So Far, with Hope of Therapy.Advances in experimental medicine and biology · 2022Article
- Article
- Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome.Translational psychiatry · 2021Article
- Genetic associations for two biological age measures point to distinct aging phenotypes.Aging cell · 2021Article
- Apolipoprotein E variants correlate with the clinical presentation of paediatric inflammatory bowel disease: A cross-sectional study.World journal of gastroenterology · 2021Article
- Inherited risk of dementia and the progression of cerebral small vessel disease and inflammatory markers in cognitively healthy midlife adults: the PREVENT-Dementia study.Neurobiology of aging · 2021Article
- APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid.Journal of Alzheimer's disease : JAD · 2021Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
The published data remain inconsistent on association between apolipoprotein E (APOE) gene variations and plasma levels of C-reactive protein (CRP), mainly because of low statistical power of previous studies. To clarify this question, we analyzed data from large population sample of randomly selected individuals from seven Czech towns (2,886 males and 3,344 females, the HAPIEE [Health, Alcohol, and Psychosocial factors In Eastern Europe] study). In both males and females, the lowest levels of plasma hsCRP were observed in the carriers of the APOE epsilon 4 epsilon 4 and epsilon 4 epsilon 3 genotypes. The median (interquartile range, IQR) concentration of hsCRP in carriers of the most common APOE epsilon 3 epsilon 3 genotype (two-thirds of participants) was 1.13 mg/l (IQR, 0.56-2.33) in men and 1.23 mg/l (IQR, 0.61-2.65) in women, compared with 0.72 mg/l (IQR, 0.61-0.86) in male and 0.72 mg/l (IQR, 0.61-0.85) in female carriers of APOE epsilon 4 epsilon 3/epsilon 4 epsilon 4 genotypes; the differences were statistically significant (p < 0.001). The association between APOE and CRP was not materially affected by adjustment for age, sex, history of cardiovascular disease, or cardiovascular risk factors. This study, the largest to date, provides robust evidence of an association between plasma hsCRP and the APOE genotype, an association not explained by history of cardiovascular disease nor its risk factors.
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