ArticleFEBS letters2010
The ND2 subunit is labeled by a photoaffinity analogue of asimicin, a potent complex I inhibitor.
Article in FEBS letters, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 57 citations in OpenAlex.
- Roles of Subunit ND2/NuoN in the Proton Pumping Coupling Mechanism of Complex I.International journal of molecular sciences · 2026Article
- Unveiling the temporal and spatial trajectories of early resistance formation during Hylocereus undatus senescence through single-cell transcriptomics.Plant molecular biology · 2025Article
- Transcriptome and Metabolome Analyses Reveal Molecular Mechanisms Regulating Growth Traits in Large Yellow Croaker (International journal of molecular sciences · 2025Article
- Article
- Characterization of the Complete Mitochondrial Genome ofInternational journal of molecular sciences · 2023Article
- Monkfish Peptides Mitigate High Fat Diet-Induced Hepatic Steatosis in Mice.Marine drugs · 2022Article
- Comparative transcriptome analysis in the hepatopancreas of Helice tientsinensis exposed to the toxic metal cadmium.Genes & genomics · 2019Article
- Transcriptome assembly and expression profiling of the molecular responses to cadmium toxicity in cerebral ganglia of wolf spider Pardosa pseudoannulata (Araneae: Lycosidae).Ecotoxicology (London, England) · 2018Article
- A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate.PloS one · 2017Article
- Gene expression profiling analysis of lung adenocarcinoma.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2016Article
- Semiquinone intermediates are involved in the energy coupling mechanism of E. coli complex I.Biochimica et biophysica acta · 2015Article
- Conserved amino acid residues of the NuoD segment important for structure and function of Escherichia coli NDH-1 (complex I).Biochemistry · 2015Article
- Article
- Role of Drug Metabolism in the Cytotoxicity and Clinical Efficacy of Anthracyclines.Current drug metabolism · 2015Review
- On the mechanism of respiratory complex I.Journal of bioenergetics and biomembranes · 2014Review
- Extremely stable soluble high molecular mass multi-protein complex with DNase activity in human placental tissue.PloS one · 2014Article
- Semiquinone and cluster N6 signals in His-tagged proton-translocating NADH:ubiquinone oxidoreductase (complex I) from Escherichia coli.The Journal of biological chemistry · 2013Article
- PGC-1β mediates adaptive chemoresistance associated with mitochondrial DNA mutations.Oncogene · 2013Article
- Identification of differential expression genes in leaves of rice (Oryza sativa L.) in response to heat stress by cDNA-AFLP analysis.BioMed research international · 2013Article
- LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets.Nucleic acids research · 2012Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
nadhubiquinone oxidoreductase (complex I) is the entry enzyme of mitochondrial oxidative phosphorylation. To obtain the structural information on inhibitor/quinone binding sites, we synthesized [3H]benzophenone-asimicin ([3H]BPA), a photoaffinity analogue of asimicin, which belongs to the acetogenin family known as the most potent complex I inhibitor. We found that [3H]BPA was photo-crosslinked to ND2, ND1 and ND5 subunits, by the three dimensional separation (blue-native/doubled SDS-PAGE) of [3H]BPA-treated bovine heart submitochondrial particles. The cross-linking was blocked by rotenone. This is the first finding that ND2 was photo-crosslinked with a potent complex I inhibitor, suggesting its involvement in the inhibitor/quinone-binding.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.