ArticleBiophysical journal2010
An off-lattice hybrid discrete-continuum model of tumor growth and invasion.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 89 citations in OpenAlex.
- Evolutionary rescue model informs strategies for driving cancer cell populations to extinction.bioRxiv : the preprint server for biology · 2025Article
- Semi-autonomous wound invasion via matrix-deposited, haptotactic cues.Journal of theoretical biology · 2023Article
- State-dependent evolutionary models reveal modes of solid tumour growth.Nature ecology & evolution · 2023Article
- The role of acoustofluidics and microbubble dynamics for therapeutic applications and drug delivery.Biomicrofluidics · 2023Review
- Extracellular matrix density regulates the formation of tumour spheroids through cell migration.PLoS computational biology · 2021Article
- Cancer systems immunology.eLife · 2020Review
- PhysiBoSS: a multi-scale agent-based modelling framework integrating physical dimension and cell signalling.Bioinformatics (Oxford, England) · 2019Article
- Mathematical Models of Cancer Cell Plasticity.Journal of oncology · 2019Review
- Integrating in vitro experiments with in silico approaches for Glioblastoma invasion: the role of cell-to-cell adhesion heterogeneity.Scientific reports · 2018Article
- Glioma growth modeling based on the effect of vital nutrients and metabolic products.Medical & biological engineering & computing · 2018Article
- A Brownian dynamics tumor progression simulator with application to glioblastoma.Convergent science physical oncology · 2018Article
- Spatially extended hybrid methods: a review.Journal of the Royal Society, Interface · 2018Review
- Modeling the two-way feedback between contractility and matrix realignment reveals a nonlinear mode of cancer cell invasion.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- A cell-centered, agent-based framework that enables flexible environment granularities.Theoretical biology & medical modelling · 2016Article
- Simulating Heterogeneous Tumor Cell Populations.PloS one · 2016Article
- The Importance of Neighborhood Scheme Selection in Agent-based Tumor Growth Modeling.Cancer informatics · 2015Article
- Influence of the microenvironment on cell fate determination and migration.Physiological genomics · 2014Review
- Evolution of intratumoral phenotypic heterogeneity: the role of trait inheritance.Interface focus · 2013Article
- Mathematical modelling of spatio-temporal glioma evolution.Theoretical biology & medical modelling · 2013Article
- Tumor cell migration in complex microenvironments.Cellular and molecular life sciences : CMLS · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
We have developed an off-lattice hybrid discrete-continuum (OLHDC) model of tumor growth and invasion. The continuum part of the OLHDC model describes microenvironmental components such as matrix-degrading enzymes, nutrients or oxygen, and extracellular matrix (ECM) concentrations, whereas the discrete portion represents individual cell behavior such as cell cycle, cell-cell, and cell-ECM interactions and cell motility by the often-used persistent random walk, which can be depicted by the Langevin equation. Using this framework of the OLHDC model, we develop a phenomenologically realistic and bio/physically relevant model that encompasses the experimentally observed superdiffusive behavior (at short times) of mammalian cells. When systemic simulations based on the OLHDC model are performed, tumor growth and its morphology are found to be strongly affected by cell-cell adhesion and haptotaxis. There is a combination of the strength of cell-cell adhesion and haptotaxis in which fingerlike shapes, characteristic of invasive tumor, are observed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.