ArticleBiophysical journal2010
Stochastic bistability and bifurcation in a mesoscopic signaling system with autocatalytic kinase.
Article in Biophysical journal, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30 citing papers in PubMed.
- Thermodynamics of Darwinian selection in molecular replicators.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Asymmetric autocatalytic reactions and their stationary distribution.Royal Society open science · 2024Article
- Bimodality in Ras signaling originates from processivity of the Ras activator SOS without deterministic bistability.Science advances · 2024Article
- MaxCal can infer models from coupled stochastic trajectories of gene expression and cell division.Biophysical journal · 2023Article
- Self-Regulated Symmetry Breaking Model for Stem Cell Differentiation.Entropy (Basel, Switzerland) · 2023Article
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- Critical Comparison of MaxCal and Other Stochastic Modeling Approaches in Analysis of Gene Networks.Entropy (Basel, Switzerland) · 2021Article
- Stochastic activation and bistability in a Rab GTPase regulatory network.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Interlinked GTPase cascades provide a motif for both robust switches and oscillators.Journal of the Royal Society, Interface · 2019Article
- Stochastic geometry sensing and polarization in a lipid kinase-phosphatase competitive reaction.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Probabilistic control of HIV latency and transactivation by the Tat gene circuit.Proceedings of the National Academy of Sciences of the United States of America · 2018Article
- A mechanism for bistability in glycosylation.PLoS computational biology · 2018Article
- Axon growth regulation by a bistable molecular switch.Proceedings. Biological sciences · 2018Article
- Building Predictive Models of Genetic Circuits Using the Principle of Maximum Caliber.Biophysical journal · 2017Article
- Processes on the emergent landscapes of biochemical reaction networks and heterogeneous cell population dynamics: differentiation in living matters.Journal of the Royal Society, Interface · 2017Review
- A minimal model of burst-noise induced bistability.PloS one · 2017Article
- The limiting dynamics of a bistable molecular switch with and without noise.Journal of mathematical biology · 2016Article
- A moment-convergence method for stochastic analysis of biochemical reaction networks.The Journal of chemical physics · 2016Article
- A Comparison of Deterministic and Stochastic Modeling Approaches for Biochemical Reaction Systems: On Fixed Points, Means, and Modes.Frontiers in genetics · 2016Article
- Promoter-mediated transcriptional dynamics.Biophysical journal · 2014Article
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2 authors.
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Abstract
Bistability is a nonlinear phenomenon widely observed in nature including in biochemical reaction networks. Deterministic chemical kinetics studied in the past has shown that bistability occurs in systems with strong (cubic) nonlinearity. For certain mesoscopic, weakly nonlinear (quadratic) biochemical reaction systems in a small volume, however, stochasticity can induce bistability and bifurcation that have no macroscopic counterpart. We report the simplest yet known reactions involving driven phosphorylation-dephosphorylation cycle kinetics with autocatalytic kinase. We show that the noise-induced phenomenon is correlated with free energy dissipation and thus conforms with the open-chemical system theory. A previous reported noise-induced bistability in futile cycles is found to have originated from the kinase synchronization in a bistable system with slow transitions, as reported here.
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