ArticleThe European journal of neuroscience2010
Quantitative analysis of postnatal neurogenesis and neuron number in the macaque monkey dentate gyrus.
Article in The European journal of neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers, 1 of them a synthesis that pooled it.
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Who cites it
72 citing papers in PubMed, 1 synthesis or guideline pooled it, 125 citations in OpenAlex.
- Hippocampal neurogenesis in adult primates: a systematic review.Molecular psychiatry · 2025Pooled it
- Spatial statistics and point pattern analysis reveal lifespan trajectories of microglial density and clustering in the primate hippocampus.Scientific reports · 2026Article
- The Dentate Gyrus Grows Throughout Life Despite Turnover of Developmentally-Born Neurons.Hippocampus · 2026Article
- Postnatal Development of the Perirhinal and Parahippocampal Cortices: A Stereological Study in Macaque Monkeys.The Journal of comparative neurology · 2026Article
- Associations Between Experience of Typical Variations in Stressors and Hippocampal Structure and Functional Connectivity in Childhood.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025Article
- Stereological Analysis of the Rhesus Monkey Perirhinal and Parahippocampal Cortices.The Journal of comparative neurology · 2024Article
- The therapeutic use of clonal neural stem cells in experimental Parkinson´s disease.Stem cell research & therapy · 2024Article
- Molecular cascade reveals sequential milestones underlying hippocampal neural stem cell development into an adult state.Cell reports · 2024Article
- Review
- Regional and cellular organization of the autism-associated protein UBE3A/E6AP and its antisense transcript in the brain of the developing rhesus monkey.Frontiers in neuroanatomy · 2024Article
- Transcription factor 4 expression in the developing non-human primate brain: a comparative analysis with the mouse brain.Frontiers in neuroanatomy · 2024Article
- Modelling adult neurogenesis in the aging rodent hippocampus: a midlife crisis.Frontiers in neuroscience · 2024Article
- Structural plasticity in the entorhinal and perirhinal cortices following hippocampal lesions in rhesus monkeys.Hippocampus · 2023Article
- Adult hippocampal neurogenesis and its impairment in Alzheimer's disease.Zoological research · 2022Review
- Singular Adult Neural Stem Cells Do Not Exist.Cells · 2022Review
- Article
- What Is the Relationship Between Hippocampal Neurogenesis Across Different Stages of the Lifespan?Frontiers in neuroscience · 2022Article
- Neurogenic-dependent changes in hippocampal circuitry underlie the procognitive effect of exercise in aging mice.iScience · 2021Article
- Life and Death of Immature Neurons in the Juvenile and Adult Primate Amygdala.International journal of molecular sciences · 2021Article
- A profusion of neural stem cells in the brain of the spiny mouse, Acomys cahirinus.Journal of anatomy · 2021Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The dentate gyrus is one of only two regions of the mammalian brain where substantial neurogenesis occurs postnatally. However, detailed quantitative information about the postnatal structural maturation of the primate dentate gyrus is meager. We performed design-based, stereological studies of neuron number and size, and volume of the dentate gyrus layers in rhesus macaque monkeys (Macaca mulatta) of different postnatal ages. We found that about 40% of the total number of granule cells observed in mature 5-10-year-old macaque monkeys are added to the granule cell layer postnatally; 25% of these neurons are added within the first three postnatal months. Accordingly, cell proliferation and neurogenesis within the dentate gyrus peak within the first 3 months after birth and remain at an intermediate level between 3 months and at least 1 year of age. Although granule cell bodies undergo their largest increase in size during the first year of life, cell size and the volume of the three layers of the dentate gyrus (i.e. the molecular, granule cell and polymorphic layers) continue to increase beyond 1 year of age. Moreover, the different layers of the dentate gyrus exhibit distinct volumetric changes during postnatal development. Finally, we observe significant levels of cell proliferation, neurogenesis and cell death in the context of an overall stable number of granule cells in mature 5-10-year-old monkeys. These data identify an extended developmental period during which neurogenesis might be modulated to significantly impact the structure and function of the dentate gyrus in adulthood.
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