ArticleJournal of computational neuroscience2010
Nonlinear cross-frequency interactions in primary auditory cortex spectrotemporal receptive fields: a Wiener-Volterra analysis.
Article in Journal of computational neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Nonlinear System Identification of Neural Systems from Neurophysiological Signals.Neuroscience · 2021Review
- Input-Specific Gain Modulation by Local Sensory Context Shapes Cortical and Thalamic Responses to Complex Sounds.Neuron · 2016Article
- Models of Neuronal Stimulus-Response Functions: Elaboration, Estimation, and Evaluation.Frontiers in systems neuroscience · 2016Review
- Human thalamus regulates cortical activity via spatially specific and structurally constrained phase-amplitude coupling.Cerebral cortex (New York, N.Y. : 1991) · 2015Article
- Octave effect in auditory attention.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Hierarchical representations in the auditory cortex.Current opinion in neurobiology · 2011Review
- Forward suppression in the auditory cortex is frequency-specific.The European journal of neuroscience · 2011Article
- Temporal coherence and attention in auditory scene analysis.Trends in neurosciences · 2011Review
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Authors and funding
2 authors.
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Abstract
The effects of nonlinear interactions between different sound frequencies on the responses of neurons in primary auditory cortex (AI) have only been investigated using two-tone paradigms. Here we stimulated with relatively dense, Poisson-distributed trains of tone pips (with frequency ranges spanning five octaves, 16 frequencies /octave, and mean rates of 20 or 120 pips /s), and examined within-frequency (or auto-frequency) and cross-frequency interactions in three types of AI unit responses by computing second-order "Poisson-Wiener" auto- and cross-kernels. Units were classified on the basis of their spectrotemporal receptive fields (STRFs) as "double-peaked", "single-peaked" or "peak-valley". Second-order interactions were investigated between the two bands of excitatory frequencies on double-peaked STRFs, between an excitatory band and various non-excitatory bands on single-peaked STRFs, and between an excitatory band and an inhibitory sideband on peak-valley STRFs. We found that auto-frequency interactions (i.e., those within a single excitatory band) were always characterized by a strong depression of (first-order) excitation that decayed with the interstimulus lag up to approximately 200 ms. That depression was weaker in cross-frequency compared to auto-frequency interactions for approximately 25% of dual-peaked STRFs, evidence of "combination sensitivity" for the two bands. Non-excitatory and inhibitory frequencies (on single-peaked and peak-valley STRFs, respectively) typically weakly depressed the excitatory response at short interstimulus lags (<50 ms), but weakly facilitated it at longer lags ( approximately 50-200 ms). Both the depression and especially the facilitation were stronger for interactions with inhibitory frequencies rather than just non-excitatory ones. Finally, facilitation in single-peaked and peak-valley units decreased with increasing stimulus density. Our results indicate that the strong combination sensitivity and cross-frequency facilitation suggested by previous two-tone-paradigm studies are much less pronounced when using more temporally-dense stimuli.
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