ArticleJournal of pharmacokinetics and pharmacodynamics2010
A new approach to the compartmental analysis in pharmacokinetics: fractional time evolution of diclofenac.
Article in Journal of pharmacokinetics and pharmacodynamics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comparison of the gamma-Pareto convolution with conventional methods of characterising metformin pharmacokinetics in dogs.Journal of pharmacokinetics and pharmacodynamics · 2020Pooled it
- Optimizing breast cancer treatment strategies through fractional-order dynamics: A computational modeling approach.PloS one · 2026Article
- CMINNs: Compartment model informed neural networks - Unlocking drug dynamics.Computers in biology and medicine · 2025Article
- Two compartmental fractional derivative model with general fractional derivative.Journal of pharmacokinetics and pharmacodynamics · 2023Review
- Fractal Kinetic Implementation in Population Pharmacokinetic Modeling.Pharmaceutics · 2023Article
- Tailored Pharmacokinetic model to predict drug trapping in long-term anesthesia.Journal of advanced research · 2021Article
- Fractional model for the spread of COVID-19 subject to government intervention and public perception.Applied mathematical modelling · 2021Article
- Fractional calculus in pharmacokinetics.Journal of pharmacokinetics and pharmacodynamics · 2018Article
- How to avoid unbounded drug accumulation with fractional pharmacokinetics.Journal of pharmacokinetics and pharmacodynamics · 2013Article
- Individualization of a pharmacokinetic model by fractional and nonlinear fit improvement.European journal of drug metabolism and pharmacokinetics · 2013Article
- Simulation of Drug Uptake in a Two Compartmental Fractional Model for a Biological System.Communications in nonlinear science & numerical simulation · 2011Article
- A nonlinear two compartmental fractional derivative model.European journal of drug metabolism and pharmacokinetics · 2011Article
- Fractional kinetics in multi-compartmental systems.Journal of pharmacokinetics and pharmacodynamics · 2010Article
- Fractional dynamics pharmacokinetics-pharmacodynamic models.Journal of pharmacokinetics and pharmacodynamics · 2010Article
- Fractional compartmental models and multi-term Mittag-Leffler response functions.Journal of pharmacokinetics and pharmacodynamics · 2010Article
- A commentary on fractionalization of multi-compartmental models.Journal of pharmacokinetics and pharmacodynamics · 2010Article
Corrections and comments
- Commented on by
- Commented on by
- Erratum issued
- Erratum issued
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study presents a new two compartmental model and its application to the evaluation of diclofenac pharmacokinetics in a small number of healthy adults, during a bioequivalence trial. In the model the integer order derivatives are replaced by derivatives of real order often called fractional order derivatives. Physically that means that a history (memory) of a biological process, realized as a transfer from one compartment to another one with the mass balance conservation, is taken into account. This kind of investigations in pharmacokinetics is founded by Dokoumetzidis and Macheras through the one compartmental models while our contribution is the analysis of multi-dimensional compartmental models with the applications of the two compartmental model in evaluation of diclofenac pharmacokinetics. Two experiments were preformed with 12 healthy volunteers with two slow release 100 mg diclofenac tablet formulations. The agreement of the values predicted by the proposed model with the values obtained through experiments is shown to be good. Thus, pharmacokinetics of slow release diclofenac can be described well by a specific two compartmental model with fractional derivatives of the same order. Parameters in the model are determined by the least-squares method and the Particle Swarm Optimization (PSO) numerical procedure is used. The results show that the fractional order two compartmental model for diclofenac is superior in comparison to the classical two compartmental model. Actually this is true in general case since the classical one is a special case of the fractional one.
Indexed as
Identifiers
20072802What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.