ArticleHernia : the journal of hernias and abdominal wall surgery2010
Experimental study comparing meshes made of polypropylene, polypropylene + polyglactin and polypropylene + titanium: inflammatory cytokines, histological changes and morphometric analysis of collagen.
Article in Hernia : the journal of hernias and abdominal wall surgery, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- What do we know about titanized polypropylene meshes? An evidence-based review of the literature.Hernia : the journal of hernias and abdominal wall surgery · 2014Pooled it
- Trial
- Comparison of intra-abdominal adhesions formation following implantation of synthetic, biosynthetic, and biologic meshes in a rat model.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2026Article
- Impact of titanium-coated polypropylene mesh on functional outcome and quality of life after inguinal hernia repair.Heliyon · 2023Article
- Analysis of tissue inflammatory response, fibroplasia, and foreign body reaction between the polyglactin suture of abdominal aponeurosis in rats and the intraperitoneal implant of polypropylene, polypropylene/polyglecaprone and polyester/porcine collagen meshes.Acta cirurgica brasileira · 2021Article
- Could polypropylene mesh impair male reproductive organs? Experimental study with different methods of implantation.Hernia : the journal of hernias and abdominal wall surgery · 2020Article
- Scar quality examination comparing titanium-coated suture material and non-coated suture material on flap donor sites in reconstructive surgery.BMC surgery · 2020Observational
- Does a bilateral polypropylene mesh alter the duct deferens morphology, testicular size and testosterone levels? Experimental study in rats.Acta cirurgica brasileira · 2020Article
- Comparative study of four different types of intraperitoneal mesh prostheses in rats.Acta cirurgica brasileira · 2019Article
- Early and late postoperative inflammatory and collagen deposition responses in three different meshes: an experimental study in rats.Hernia : the journal of hernias and abdominal wall surgery · 2014Article
- Effects of mesenchymal stem cell and fibroblast coating on immunogenic potential of prosthetic meshes in vitro.Surgical endoscopy · 2014Article
- Comparative study of shrinkage, inflammatory response and fibroplasia in heavyweight and lightweight meshes.Hernia : the journal of hernias and abdominal wall surgery · 2013Article
- Inflammatory reaction and neotissue maturation in the early host tissue incorporation of polypropylene prostheses.Hernia : the journal of hernias and abdominal wall surgery · 2012Article
- Serum profile of pro- and anti-inflammatory cytokines in rats following implantation of low-temperature plasma-modified titanium plates.Journal of materials science. Materials in medicine · 2012Article
- A preclinical evaluation of alternative synthetic biomaterials for fascial defect repair using a rat abdominal hernia model.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeIncisional hernia occurs in approximately 11% of all laparotomies. Changes in collagen have been closely implicated in its pathogenesis. The high recurrence rate (45-54%) after primary suture has stimulated the development of meshes. Currently, meshes are the biomaterials implant group most used in medicine. This study aims to compare the serum and tissue inflammatory responses and collagen deposition caused by meshes made of polypropylene, polypropylene + polyglactin and polypropylene + titanium.
methodsThirty Wistar rats were divided into three groups. In group I, a high-density polypropylene mesh was positioned on the abdominal wall. In groups II and III, low-density meshes were used in associations with polyglactin and titanium, respectively. Immediately before the operation and on the first, third and fortieth postoperative days, pro-inflammatory cytokines were assayed. On the 40th postoperative day, the region of the inserted prosthesis was biopsied. The tissue inflammatory reaction was evaluated using a scale for objective scoring. For collagen, picrosirius was used with data reading using the Image Tool computer software.
resultsCytokines: there were no statistically significant differences between the groups. HISTOLOGY: on the 40th postoperative day in group I, there were fewer inflammatory tissue response and greater collagen deposition (P < 0.01). In group II, there were greater inflammatory tissue response and less collagen deposition (P < 0.01). Group III presented intermediate values between groups I and II.
conclusionsThere were no significant differences in cytokine levels between the groups in the present study. In the animals with the polypropylene + polyglactin mesh implant there was the most intense inflammatory process with lower tissue maturation and collagen deposition on the 40th postoperative day. The polypropylene mesh presented a less severe late inflammatory process, with greater tissue maturation and collagen deposition. The polypropylene + titanium mesh presented intermediate values between the others.
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