ArticleJournal of ocular biology, diseases, and informatics2008
Comparison of gene expression during in vivo and in vitro postnatal retina development.
Article in Journal of ocular biology, diseases, and informatics, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- The Effects of Cannabinoids on Ischemic Stroke-Associated Neuroinflammation: A Systematic Review.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Pooled it
- Posttranscriptional regulation of the T-box gene midline via the 3'UTR in Drosophila is complex and cell- and tissue-dependent.Genetics · 2024Article
- Dopamine modulates the retinal clock through melanopsin-dependent regulation of cholinergic waves during development.BMC biology · 2023Article
- Transcriptome profiling of Staphylococci-infected cow mammary gland parenchyma.BMC veterinary research · 2017Article
- Immunocytochemical Profiling of Cultured Mouse Primary Retinal Cells.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- Histone Deacetylase 1 Is Essential for Rod Photoreceptor Differentiation by Regulating Acetylation at Histone H3 Lysine 9 and Histone H4 Lysine 12 in the Mouse Retina.The Journal of biological chemistry · 2017Article
- LSD1-Mediated Demethylation of H3K4me2 Is Required for the Transition from Late Progenitor to Differentiated Mouse Rod Photoreceptor.Molecular neurobiology · 2016Article
- Microarray and morphological analysis of early postnatal CRB2 mutant retinas on a pure C57BL/6J genetic background.PloS one · 2013Article
- Specific protein kinase C isoforms are required for rod photoreceptor differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledRetina explants are widely used as a model of neural development. To define the molecular basis of differences between the development of retina in vivo and in vitro during the early postnatal period, we carried out a series of microarray comparisons using mouse retinas. About 75% of 8,880 expressed genes from retina explants kept the same expression volume and pattern as the retina in vivo. Fewer than 6% of the total gene population was changed at two consecutive time points, and only about 1% genes showed more than a threefold change at any time point studied. Functional Gene Ontology (GO) mapping for both changed and unchanged genes showed similar distribution patterns, except that more genes were changed in the GO clusters of response to stimuli and carbohydrate metabolism. Three distinct expression patterns of genes preferentially expressed in rod photoreceptors were observed in the retina explants. Some genes showed a lag in increased expression, some showed no change, and some continued to have a reduced level of expression. An early downregulation of cyclin D1 in the explanted retina might explain the reduction in numbers of precursors in explanted retina and suggests that external factors are required for maintenance of cyclin D1. The global view of gene profiles presented in this study will help define the molecular changes in retina explants over time and will provide criteria to define future changes that improve this model system. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1007/s12177-008-9009-z) contains supplementary material, which is available to authorized users.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.