ArticlePloS one2010
The quantitative genetics of phenotypic robustness.
Article in PloS one, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Effects of Sex on Intra-Individual Variance in Urinary Solutes in Stone-Formers Collected from a Single Clinical Laboratory.PloS one · 2013Trial
- Environmental perturbation increases gene expression variability and unmasks genetic regulation for transcriptional robustness.bioRxiv : the preprint server for biology · 2026Article
- A model of developmental canalization, applied to human cranial form.PLoS computational biology · 2021Article
- Using single-plant-omics in the field to link maize genes to functions and phenotypes.Molecular systems biology · 2020Article
- Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk.JAMA psychiatry · 2019Article
- QTL Mapping on a Background of Variance Heterogeneity.G3 (Bethesda, Md.) · 2018Article
- Single-cell profiling screen identifies microtubule-dependent reduction of variability in signaling.Molecular systems biology · 2018Article
- A sibling method for identifying vQTLs.PloS one · 2018Article
- Caenorhabditis elegans Genes Affecting Interindividual Variation in Life-span Biomarker Gene Expression.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- The Genetic Basis of Plant Architecture in 10 Maize Recombinant Inbred Line Populations.Plant physiology · 2017Article
- Resolving the Complex Genetic Basis of Phenotypic Variation and Variability of Cellular Growth.Genetics · 2017Article
- The mutational structure of metabolism in Caenorhabditis elegans.Evolution; international journal of organic evolution · 2016Article
- Genetic structure of phenotypic robustness in the collaborative cross mouse diallel panel.Journal of evolutionary biology · 2016Article
- Mutation Is a Sufficient and Robust Predictor of Genetic Variation for Mitotic Spindle Traits in Caenorhabditis elegans.Genetics · 2016Article
- Article
- Developmental mechanisms underlying variable, invariant and plastic phenotypes.Annals of botany · 2016Review
- Life history as a constraint on plasticity: developmental timing is correlated with phenotypic variation in birds.Heredity · 2015Article
- Pervasive robustness in biological systems.Nature reviews. Genetics · 2015Review
- Within-strain variation in behavior differs consistently between common inbred strains of mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2015Article
- Genetic variation in the nuclear and organellar genomes modulates stochastic variation in the metabolome, growth, and defense.PLoS genetics · 2015Article
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2 authors.
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Abstract
Phenotypic robustness, or canalization, has been extensively investigated both experimentally and theoretically. However, it remains unknown to what extent robustness varies between individuals, and whether factors buffering environmental variation also buffer genetic variation. Here we introduce a quantitative genetic approach to these issues, and apply this approach to data from three species. In mice, we find suggestive evidence that for hundreds of gene expression traits, robustness is polymorphic and can be genetically mapped to discrete genomic loci. Moreover, we find that the polymorphisms buffering genetic variation are distinct from those buffering environmental variation. In fact, these two classes have quite distinct mechanistic bases: environmental buffers of gene expression are predominantly sex-specific and trans-acting, whereas genetic buffers are not sex-specific and often cis-acting. Data from studies of morphological and life-history traits in plants and yeast support the distinction between polymorphisms buffering genetic and environmental variation, and further suggest that loci buffering different types of environmental variation do overlap with one another. These preliminary results suggest that naturally occurring polymorphisms affecting phenotypic robustness could be abundant, and that these polymorphisms may generally buffer either genetic or environmental variation, but not both.
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