ArticleLeukemia2010
Alloreactive microenvironment after human hematopoietic cell transplantation induces genomic alterations in epithelium through an ROS-mediated mechanism: in vivo and in vitro study and implications to secondary neoplasia.
Article in Leukemia, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The trial behind it
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Trial
- Oxidative Stress Early After Hematopoietic Stem Cell Transplant.Transplantation and cellular therapy · 2025Article
- Both Th1 and Th2 CD4 + T-Cell Lineage Infiltrations Decrease in Post-hematopoietic Stem Cell Transplantation Colon Adenoma.Journal of gastrointestinal cancer · 2024Article
- Metabolic instruction of the graft-versus-leukemia immunity.Frontiers in immunology · 2024Review
- Oral microbial changes and oral disease management before and after the treatment of hematological malignancies: a narrative review.Clinical oral investigations · 2023Review
- Secondary oral cancer following hematopoietic cell transplantation.Bone marrow transplantation · 2021Article
- Occurrence of quadruple squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation for leukemia: A case report.Oncology letters · 2021Article
- IDO1 scavenges reactive oxygen species in myeloid-derived suppressor cells to prevent graft-versus-host disease.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Busulfan Pharmacokinetics and Precision Dosing: Are Patients with Fanconi Anemia Different?Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation · 2019Article
- Second Malignancies after Hematopoietic Stem Cell Transplantation.Current treatment options in oncology · 2018Review
- Late effects in patients with Fanconi anemia following allogeneic hematopoietic stem cell transplantation from alternative donors.Bone marrow transplantation · 2016Article
- p53 phosphorylation and TP53 copy-number alterations in chronic graft-versus-host oral lichen preceding squamous cell carcinoma.The Journal of investigative dermatology · 2014Article
- Nuclear Nox4-derived reactive oxygen species in myelodysplastic syndromes.BioMed research international · 2014Article
- Thiol/redox metabolomic profiling implicates GSH dysregulation in early experimental graft versus host disease (GVHD).PloS one · 2014Article
- Oxidative stress leads to increased mutation frequency in a murine model of myelodysplastic syndrome.Leukemia research · 2014Article
- Article
- DNA damage and repair in epithelium after allogeneic hematopoietic stem cell transplantation.International journal of molecular sciences · 2012Review
- Oral epithelial dysplasia and squamous cell carcinoma following allogeneic hematopoietic stem cell transplantation: clinical presentation and treatment outcomes.Bone marrow transplantation · 2011Article
- DNA chimerism and its consequences after allogeneic hematopoietic cell transplantation.Chimerism · 2011Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We hypothesized that chronic tissue stress due to interaction of alloreactive donor cells with host epithelium after allogeneic hematopoietic cell transplantation (allo-HCT) may cause genomic alterations. We therefore analyzed 176 buccal samples obtained from 71 unselected allotransplanted patients for microsatellite instability (MSI). MSI was observed in 52% of allotransplanted patients but never in 31 healthy or autotransplanted controls. The patient age, the donor age, a female-to-male transplantation and a low number of CD34(+) cells in the graft were significantly correlated with genomic instability. There was a trend for increasing risk of MSI for patients who experienced severe graft-vs-host disease. Secondary malignancy was diagnosed in five (14%) of the MSI(+) and only in one (3%) MSI(-) patient. In an in vitro model of mutation analysis we found significant induction of frameshift mutations and DNA strand breaks in HaCaT keratinocytes co-cultured with mixed lymphocyte cultures (MLCs) but not after their exposure to interferon-gamma, tumor necrosis factor-alpha, transforming growth factor-beta (TGF-beta), MLC supernatant, peripheral blood mononuclear cells (PBMCs) or phytohemagglutinin-stimulated PBMC. A reactive oxygen species-mediated mechanism is implicated. The in vivo and in vitro data of our study show that alloreactions after allo-HCT may induce genomic alterations in epithelium. Progress in understanding DNA damage and repair after allo-HCT can potentially provide molecular biomarkers and therapeutic targets.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.