Trial reportThe Journal of investigative dermatology2010
Cathepsin S elicits itch and signals via protease-activated receptors.
Trial report in The Journal of investigative dermatology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 106 citations in OpenAlex.
- Cowhage-induced itch as an experimental model for pruritus. A comparative study with histamine-induced itch.PloS one · 2011Trial
- Transient Receptor Potential (TRP) Channels as Fundamental Regulators of Fibrosis and Pruritus-A New Therapeutic Target for Pathological Scar Management.International journal of molecular sciences · 2026Review
- The neuro-immune insights of itch: peripheral mechanisms and central glial contributions.Cellular & molecular biology letters · 2026Review
- The pH-Dependent Specificity of Cathepsin S and Its Implications for Inflammatory Communications and Disease.Biochemistry · 2025Article
- Prevalence and Mechanisms of Itch in Chronic Wounds: A Narrative Review.Journal of clinical medicine · 2025Review
- Protease-activated receptor 2 attenuates doxorubicin-induced apoptosis in colon cancer cells.Journal of cell communication and signaling · 2023Article
- Sensing of protease activity as a triggering mechanism of Th2 cell immunity and allergic disease.Frontiers in allergy · 2023Review
- Critical Players and Therapeutic Targets in Chronic Itch.International journal of molecular sciences · 2022Review
- Punctate Administration of Ficin as a human and animal model of non-histaminergic itch.Journal of the European Academy of Dermatology and Venereology : JEADV · 2022Article
- Connections between Immune-Derived Mediators and Sensory Nerves for Itch Sensation.International journal of molecular sciences · 2021Review
- Skullcapflavone II Suppresses TNF-α/IFN-γ-Induced TARC, MDC, and CTSS Production in HaCaT Cells.International journal of molecular sciences · 2021Article
- Article
- Advances in Understanding the Initial Steps of Pruritoceptive Itch: How the Itch Hits the Switch.International journal of molecular sciences · 2020Review
- Cathepsin S: investigating an old player in lung disease pathogenesis, comorbidities, and potential therapeutics.Respiratory research · 2020Review
- PAR2 Pepducin-Based Suppression of Inflammation and Itch in Atopic Dermatitis Models.The Journal of investigative dermatology · 2019Article
- Mas-Related G-Protein Coupled Receptors and Cowhage-Induced Itch.The Journal of investigative dermatology · 2018Article
- Altered expression of target genes of spinal cord in different itch models compared with capsaicin assessed by RT-qPCR validation.Oncotarget · 2017Article
- Tlx3 Function in the Dorsal Root Ganglion is Pivotal to Itch and Pain Sensations.Frontiers in molecular neuroscience · 2017Article
- Mediators of Chronic Pruritus in Atopic Dermatitis: Getting the Itch Out?Clinical reviews in allergy & immunology · 2016Review
- Trp channels and itch.Seminars in immunopathology · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
PubMed holds no abstract for this paper.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.