ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2010
A novel mechanism and treatment target for presynaptic abnormalities in specific striatal regions in schizophrenia.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 54 citations in OpenAlex.
- The interplay between age at menopause and synaptic integrity on Alzheimer's disease risk in women.Science advances · 2025Article
- A multilayer network analysis of Alzheimer's disease pathogenesis: Roles for p-tau, synaptic peptides, and physical activity.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Effect of antipsychotic drugs on group II metabotropic glutamate receptor expression and epigenetic control in postmortem brains of schizophrenia subjects.Translational psychiatry · 2024Article
- The Relationship between SNAP25 and Some Common Human Neurological Syndromes.Current pharmaceutical design · 2024Review
- Tripartite Relationship Among Synaptic, Amyloid, and Tau Proteins: An In Vivo and Postmortem Study.Neurology · 2021Article
- Therapeutic effects of astragaloside IV andPeerJ · 2021Article
- A comparison of regional brain volumes and white matter connectivity in subjects with stimulant induced psychosis versus schizophrenia.Psychopharmacology · 2019Observational
- The SNAP25 Interactome in Ventromedial Caudate in Schizophrenia Includes the Mitochondrial Protein ARF1.Neuroscience · 2019Article
- Reduced SNAP25 Protein Fragmentation Contributes to SNARE Complex Dysregulation in Schizophrenia Postmortem Brain.Neuroscience · 2019Article
- STX1A gene variations contribute to the susceptibility of children attention-deficit/hyperactivity disorder: a case-control association study.European archives of psychiatry and clinical neuroscience · 2019Article
- The synaptic pathology of cognitive life .Dialogues in clinical neuroscience · 2019Review
- Human Hippocampal Neurogenesis Persists in Aged Adults and Alzheimer's Disease Patients.Cell stem cell · 2019Article
- Novel SNARE Complex Polymorphisms Associated with Multiple Sclerosis: Signs of Synaptopathy in Multiple SclerosisBalkan medical journal · 2019Article
- Effects of haloperidol and clozapine on synapse-related gene expression in specific brain regions of male rats.European archives of psychiatry and clinical neuroscience · 2018Article
- Frontotemporal dysregulation of the SNARE protein interactome is associated with faster cognitive decline in old age.Neurobiology of disease · 2018Article
- A Multilevel Functional Study of aThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Presynaptic proteins complexin-I and complexin-II differentially influence cognitive function in early and late stages of Alzheimer's disease.Acta neuropathologica · 2017Article
- Quantitative mass spectrometry reveals changes in SNAP-25 isoforms in schizophrenia.Schizophrenia research · 2016Article
- SNARE complex in developmental psychiatry: neurotransmitter exocytosis and beyond.Journal of neural transmission (Vienna, Austria : 1996) · 2016Review
- Dysregulations of Synaptic Vesicle Trafficking in Schizophrenia.Current psychiatry reports · 2016Review
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 4 countries.
Funding
Abstract
Abnormalities of amount and function of presynaptic terminals may have an important role in the mechanism of illness in schizophrenia. The SNARE proteins (SNAP-25, syntaxin, and VAMP) are enriched in presynaptic terminals, where they interact to form a functional complex to facilitate vesicle fusion. SNARE protein amounts are altered in the cortical regions in schizophrenia, but studies of protein-protein interactions are limited. We extended these investigations to the striatal regions (such as the nucleus accumbens, ventromedial caudate (VMC), and dorsal caudate) relevant to disease symptoms. In addition to measuring SNARE protein levels, we studied SNARE protein-protein interactions using a novel ELISA method. The possible effect of antipsychotic treatment was investigated in parallel in the striatum of rodents that were administered haloperidol and clozapine. In schizophrenia samples, compared with controls, SNAP-25 was 32% lower (P=0.015) and syntaxin was 26% lower (P=0.006) in the VMC. In contrast, in the same region, SNARE protein-protein interactions were higher in schizophrenia (P=0.008). Confocal microscopy of schizophrenia and control VMC showed qualitatively similar SNARE protein immunostaining. Haloperidol treatment of rats increased levels of SNAP-25 (mean 24%, P=0.003), syntaxin (mean 18%, P=0.010), and VAMP (mean 16%, P=0.001), whereas clozapine increased only the VAMP level (mean 13%, P=0.004). Neither drug altered SNARE protein-protein interactions. These results indicate abnormalities of amount and interactions of proteins directly related to presynaptic function in the VMC in schizophrenia. SNARE proteins and their interactions may be a novel target for the development of therapeutics.
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