ArticleInvestigative ophthalmology & visual science2010
The zebrafish galectin Drgal1-l2 is expressed by proliferating Müller glia and photoreceptor progenitors and regulates the regeneration of rod photoreceptors.
Article in Investigative ophthalmology & visual science, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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Who cites it
45 citing papers in PubMed.
- Article
- Article
- A Zebrafish Galectin-1 Isoform Is Expressed in Skin and Gills and Binds to Bacteria, Bacterial Adhesin Receptors, and Epidermal Mucus Glycans.International journal of molecular sciences · 2026Article
- Article
- A "proto" type galectin expressed in striped bass (Frontiers in cellular and infection microbiology · 2025Article
- Comparison of the effects of EGF, FGF-b, and NGF on the proliferation, migration, and reprogramming of primary rat Müller cells.Frontiers in cellular neuroscience · 2024Article
- leptin b and its regeneration enhancer illustrate the regenerative features of zebrafish hearts.Developmental dynamics : an official publication of the American Association of Anatomists · 2024Article
- An Overview towards Zebrafish Larvae as a Model for Ocular Diseases.International journal of molecular sciences · 2023Review
- Cost-effective strategies to knock down genes of interest in the retinas of adult zebrafish.Frontiers in cellular neuroscience · 2023Article
- A multidimensional metabolomics workflow to image biodistribution and evaluate pharmacodynamics in adult zebrafish.Disease models & mechanisms · 2022Article
- Review
- Galectins in the Pathogenesis of Common Retinal Disease.Frontiers in pharmacology · 2021Review
- A Comparative Analysis of Gene and Protein Expression Throughout a Full 28-Day Retinal Regeneration Time-Course in Adult Zebrafish.Frontiers in cell and developmental biology · 2021Article
- Human red and green cone opsins areThe Journal of biological chemistry · 2019Article
- Pregnancy Galectinology: Insights Into a Complex Network of Glycan Binding Proteins.Frontiers in immunology · 2019Review
- Nanoparticle-mediated siRNA Gene-silencing in Adult Zebrafish Heart.Journal of visualized experiments : JoVE · 2018Article
- Extraocular muscle regeneration in zebrafish requires late signals from Insulin-like growth factors.PloS one · 2018Article
- Temporally distinct transcriptional regulation of myocyte dedifferentiation and Myofiber growth during muscle regeneration.BMC genomics · 2017Article
- Functions of galectins as 'self/non-self'-recognition and effector factors.Pathogens and disease · 2017Review
- Correlation between photoreceptor injury-regeneration and behavior in a zebrafish model.Neural regeneration research · 2017Article
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6 authors.
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Abstract
purposeThe purpose of this study was to identify secreted proteins in the retina of the adult zebrafish that are induced by the selective death of photoreceptors and to test experimentally the function of these proteins during the regeneration of photoreceptors.
methodsInduced selective death of photoreceptors in the retina of the adult zebrafish was combined with in situ hybridization and immunocytochemistry to identify the induced cellular expression of the secreted beta-galactoside binding protein Galectin 1-like 2 (Drgal1-L2). Electroporation of morpholino oligonucleotides was used to knock down protein synthesis, and regenerated photoreceptors were counted in control and experimental retinas after labeling with cell type-specific RNA probes.
resultsExpression analysis and immunocytochemistry showed that Drgal1-L2 is induced de novo by photoreceptor death and is synthesized by microglia and proliferating Müller glia and their mitotic progeny. Knockdown of Drgal1-L2 expression in Müller glia results in reduced regeneration of rod photoreceptors without affecting injury-induced proliferation or the regeneration of cone photoreceptors.
conclusionsBased on these data, the authors conclude that Drgal1-L2 is induced by photoreceptor cell death and secreted by stem cells and neuronal progenitors and that it regulates the regeneration of rod photoreceptors. Drgal1-L2 is the first secreted factor shown to regulate aspects of regenerative neurogenesis in the teleost retina.
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