Evidence map›Paper›PMID 20071648›Full record

SynthesisThe American journal of clinical nutrition2010

Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease.

Patty W Siri-Tarino, Qi Sun, Frank B Hu, Ronald M Krauss

Registry-linked trialOpen access · bronzeAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The American journal of clinical nutrition, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03214861 (Carbohydrate Quality and Quantity and Risk of Coronary Heart Disease Among US Women and Men.), which is not on this map. Cited by 349 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
349citing papers in PubMed, 14 pooled it
55.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03214861 completednot on this map

Carbohydrate Quality and Quantity and Risk of Coronary Heart Disease Among US Women and Men.

TypeobservationalSponsorHarvard School of Public Health (HSPH)Ran1976 to 2012Enrolled117,885ConditionsCoronary Heart DiseaseArmsCarbohydrate quality
3 · Its place in the literature

Who cites it

349 citing papers in PubMed, 14 syntheses or guidelines pooled it, 1,244 citations in OpenAlex.

  1. Pooled it
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  7. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  8. Reduction in saturated fat intake for cardiovascular disease.The Cochrane database of systematic reviews · 2020
    Pooled it
  9. Pooled it
  10. Pooled it
  11. Guideline
  12. Atencion primaria · 2018
    Guideline
  13. Pooled it
  14. Pooled it
  15. Trial
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  20. Trial

289 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Patty W Siri-TarinoChildren's Hospital, Oakland Research Institute Oakland, CA, USA.
Qi Sun
Frank B Hu
Ronald M Krauss
Children’s Institute · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
DIETARY PATTERNS AND RISK OF CARDIOVASCULAR DISEASER01HL060712 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI HU, FRANK B, QI, QIBIN · 1998 to 2021
$8.0M
NCRR NIH HHS UL1 RR024131-01NHLBI NIH HHS HL60712
6 · The paper itself

Abstract

backgroundA reduction in dietary saturated fat has generally been thought to improve cardiovascular health.

objectiveThe objective of this meta-analysis was to summarize the evidence related to the association of dietary saturated fat with risk of coronary heart disease (CHD), stroke, and cardiovascular disease (CVD; CHD inclusive of stroke) in prospective epidemiologic studies.

designTwenty-one studies identified by searching MEDLINE and EMBASE databases and secondary referencing qualified for inclusion in this study. A random-effects model was used to derive composite relative risk estimates for CHD, stroke, and CVD.

resultsDuring 5-23 y of follow-up of 347,747 subjects, 11,006 developed CHD or stroke. Intake of saturated fat was not associated with an increased risk of CHD, stroke, or CVD. The pooled relative risk estimates that compared extreme quantiles of saturated fat intake were 1.07 (95% CI: 0.96, 1.19; P = 0.22) for CHD, 0.81 (95% CI: 0.62, 1.05; P = 0.11) for stroke, and 1.00 (95% CI: 0.89, 1.11; P = 0.95) for CVD. Consideration of age, sex, and study quality did not change the results.

conclusionsA meta-analysis of prospective epidemiologic studies showed that there is no significant evidence for concluding that dietary saturated fat is associated with an increased risk of CHD or CVD. More data are needed to elucidate whether CVD risks are likely to be influenced by the specific nutrients used to replace saturated fat.

Indexed as

Cardiovascular DiseasesCohort StudiesCoronary DiseaseDietDietary FatsFatty AcidsHumansProspective StudiesRisk FactorsStrokeDietary FatsFatty Acids

Identifiers

PMID20071648
PMCPMC2824152
OpenAlexW2097301645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.