ArticleJournal of virology2010
Identification of host factors involved in borna disease virus cell entry through a small interfering RNA functional genetic screen.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Cathepsins in cellular entry of human pathogenic viruses.Journal of virology · 2025Review
- Evolutionary Selection of the Nuclear Localization Signal in the Viral Nucleoprotein Leads to Host Adaptation of the GenusViruses · 2020Article
- Genome-wide profiling of long noncoding RNA expression patterns and CeRNA analysis in mouse cortical neurons infected with different strains of borna disease virus.Genes & diseases · 2019Article
- Molecular Mechanisms of Innate Immune Inhibition by Non-Segmented Negative-Sense RNA Viruses.Journal of molecular biology · 2016Review
- Co-expression analysis of differentially expressed genes in hepatitis C virus-induced hepatocellular carcinoma.Molecular medicine reports · 2015Article
- Specific inhibition of diverse pathogens in human cells by synthetic microRNA-like oligonucleotides inferred from RNAi screens.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- A loss of function analysis of host factors influencing Vaccinia virus replication by RNA interference.PloS one · 2014Article
- Analysis of borna disease virus trafficking in live infected cells by using a virus encoding a tetracysteine-tagged p protein.Journal of virology · 2013Article
- Comprehensive analysis of endogenous bornavirus-like elements in eukaryote genomes.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Analysis of virion-incorporated host proteins required for herpes simplex virus type 1 infection through a RNA interference screen.PloS one · 2013Article
- Cell-based genomic screening: elucidating virus-host interactions.Current opinion in virology · 2012Review
- Non-retroviral fossils in vertebrate genomes.Viruses · 2011Review
- The association of viral proteins with host cell dynein components during virus infection.The FEBS journal · 2011Review
- Article
- Enhancers of adeno-associated virus AAV2 transduction via high throughput siRNA screening.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Article
- A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats.Experimental neurology · 2010Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Borna disease virus (BDV), the prototypic member of the Bornaviridae family, within the order Mononegavirales, is highly neurotropic and constitutes an important model system for the study of viral persistence in the central nervous system (CNS) and associated disorders. The virus surface glycoprotein (G) has been shown to direct BDV cell entry via receptor-mediated endocytosis, but the mechanisms governing cell tropism and propagation of BDV within the CNS are unknown. We developed a small interfering RNA (siRNA)-based screening to identify cellular genes and pathways that specifically contribute to BDV G-mediated cell entry. Our screen relied on silencing-mediated increased survival of cells infected with rVSVDeltaG*/BDVG, a cytolytic recombinant vesicular stomatitis virus expressing BDV G that mimics the cell tropism and entry pathway of bona fide BDV. We identified 24 cellular genes involved in BDV G-mediated cell entry. Identified genes are known to participate in a broad range of distinct cellular functions, revealing a complex process associated with BDV cell entry. The siRNA-based screening strategy we have developed should be applicable to identify cellular genes contributing to cell entry mediated by surface G proteins of other viruses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.