ArticleJournal of virology2010
Assessment of seasonal influenza A virus-specific CD4 T-cell responses to 2009 pandemic H1N1 swine-origin influenza A virus.
Article in Journal of virology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed, 101 citations in OpenAlex.
- Trial
- Influenza.Nature reviews. Disease primers · 2026Review
- Article
- Phenotypes and Functions of SARS-CoV-2-Reactive T Cells.Molecules and cells · 2021Review
- Mass Cytometry Defines Virus-Specific CD4ImmunoHorizons · 2020Article
- CD4Cell reports · 2020Article
- Multi-HLA class II tetramer analyses of citrulline-reactive T cells and early treatment response in rheumatoid arthritis.BMC immunology · 2020Article
- Bioinformatics design and experimental validation of influenza A virus multi-epitopes that induce neutralizing antibodies.Archives of virology · 2020Article
- Recombinant HA-based vaccine outperforms split and subunit vaccines in elicitation of influenza-specific CD4 T cells and CD4 T cell-dependent antibody responses in humans.NPJ vaccines · 2020Article
- Escherichiacoli-Specific CD4+ T Cells Have Public T-Cell Receptors and Low Interleukin 10 Production in Crohn's Disease.Cellular and molecular gastroenterology and hepatology · 2020Observational
- Review
- Highly conserved hemagglutinin peptides of H1N1 influenza virus elicit immune response.3 Biotech · 2018Article
- A Lipid/DNA Adjuvant-Inactivated Influenza Virus Vaccine Protects Rhesus Macaques From Uncontrolled Virus Replication After Heterosubtypic Influenza A Virus Challenge.The Journal of infectious diseases · 2018Article
- Unsupervised capture and profiling of rare immune cells using multi-directional magnetic ratcheting.Lab on a chip · 2018Article
- Integrative Physiology of Pneumonia.Physiological reviews · 2018Review
- A humanized mouse model identifies key amino acids for low immunogenicity of H7N9 vaccines.Scientific reports · 2017Article
- Circulating Memory CD4+ T Cells Target Conserved Epitopes of Rhinovirus Capsid Proteins and Respond Rapidly to Experimental Infection in Humans.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Efficient ex vivo analysis of CD4+ T-cell responses using combinatorial HLA class II tetramer staining.Nature communications · 2016Article
- Heterosubtypic T-Cell Immunity to Influenza in Humans: Challenges for Universal T-Cell Influenza Vaccines.Frontiers in immunology · 2016Review
- Measuring Cellular Immunity to Influenza: Methods of Detection, Applications and Challenges.Vaccines · 2015Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Very limited evidence has been reported to show human adaptive immune responses to the 2009 pandemic H1N1 swine-origin influenza A virus (S-OIV). We studied 17 S-OIV peptides homologous to immunodominant CD4 T epitopes from hemagglutinin (HA), neuraminidase (NA), nuclear protein (NP), M1 matrix protein (MP), and PB1 of a seasonal H1N1 strain. We concluded that 15 of these 17 S-OIV peptides would induce responses of seasonal influenza virus-specific T cells. Of these, seven S-OIV sequences were identical to seasonal influenza virus sequences, while eight had at least one amino acid that was not conserved. T cells recognizing epitopes derived from these S-OIV antigens could be detected ex vivo. Most of these T cells expressed memory markers, although none of the donors had been exposed to S-OIV. Functional analysis revealed that specific amino acid differences in the sequences of these S-OIV peptides would not affect or partially affect memory T-cell responses. These findings suggest that without protective antibody responses, individuals vaccinated against seasonal influenza A may still benefit from preexisting cross-reactive memory CD4 T cells reducing their susceptibility to S-OIV infection.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.