ArticleAmerican journal of physiology. Endocrinology and metabolism2010
Combining short-term metformin treatment and one bout of exercise does not increase insulin action in insulin-resistant individuals.
Article in American journal of physiology. Endocrinology and metabolism, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
71 citing papers in PubMed, 2 syntheses or guidelines pooled it, 144 citations in OpenAlex.
- After Dinner Rest a While, After Supper Walk a Mile? A Systematic Review with Meta-analysis on the Acute Postprandial Glycemic Response to Exercise Before and After Meal Ingestion in Healthy Subjects and Patients with Impaired Glucose Tolerance.Sports medicine (Auckland, N.Z.) · 2023Pooled it
- The effect of SGLT-2 inhibitors on cardiorespiratory fitness capacity: A systematic review and meta-analysis.Frontiers in physiology · 2022Pooled it
- Metformin attenuates metabolic insulin sensitivity and insulin-stimulated carbohydrate oxidation after high-intensity exercise training in adults at risk for metabolic syndrome.Diabetes, obesity & metabolism · 2026Trial
- Metformin Blunts Vascular Insulin Sensitivity After Exercise Training in Adults at Risk for Metabolic Syndrome.The Journal of clinical endocrinology and metabolism · 2026Trial
- Morning exercise and pre-breakfast metformin interact to reduce glycaemia in people with type 2 diabetes: a randomized crossover trial.The Journal of physiology · 2024Trial
- A randomized clinical trial comparing low-fat with precision nutrition-based diets for weight loss: impact on glycemic variability and HbA1c.The American journal of clinical nutrition · 2023Trial
- Trial
- Frequency of Interruptions to Sitting Time: Benefits for Postprandial Metabolism in Type 2 Diabetes.Diabetes care · 2021Trial
- The Effect of Metformin on Self-Selected Exercise Intensity in Healthy, Lean Males: A Randomized, Crossover, Counterbalanced Trial.Frontiers in endocrinology · 2021Trial
- Metformin alters skeletal muscle transcriptome adaptations to resistance training in older adults.Aging · 2020Trial
- Exercise improves metformin 72-h glucose control by reducing the frequency of hyperglycemic peaks.Acta diabetologica · 2020Trial
- Exercise-Induced Improvements in Postprandial Glucose Response Are Blunted by Pre-Exercise Hyperglycemia: A Randomized Crossover Trial in Healthy Individuals.Frontiers in endocrinology · 2020Trial
- Metformin does not compromise energy status in human skeletal muscle at rest or during acute exercise: A randomised, crossover trial.Physiological reports · 2019Trial
- Metformin inhibits mitochondrial adaptations to aerobic exercise training in older adults.Aging cell · 2019Trial
- Abundance in proteins expressed after functional electrical stimulation cycling or arm cycling ergometry training in persons with chronic spinal cord injury.The journal of spinal cord medicine · 2017Trial
- Benefits of a Paleolithic diet with and without supervised exercise on fat mass, insulin sensitivity, and glycemic control: a randomized controlled trial in individuals with type 2 diabetes.Diabetes/metabolism research and reviews · 2017Trial
- Does metformin modify the effect on glycaemic control of aerobic exercise, resistance exercise or both?Diabetologia · 2013Trial
- Pancreatic β-cell function is a stronger predictor of changes in glycemic control after an aerobic exercise intervention than insulin sensitivity.The Journal of clinical endocrinology and metabolism · 2013Trial
- Mechanisms of glucose lowering of dipeptidyl peptidase-4 inhibitor sitagliptin when used alone or with metformin in type 2 diabetes: a double-tracer study.Diabetes care · 2013Trial
- Metformin modifies the exercise training effects on risk factors for cardiovascular disease in impaired glucose tolerant adults.Obesity (Silver Spring, Md.) · 2013 · on this mapTrial
11 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
Results from the Diabetes Prevention Program highlight the effectiveness of metformin or regular physical activity in the prevention of type 2 diabetes. Independently, metformin and exercise increase insulin sensitivity, but they have not been studied in combination. To assess the combined effects, insulin-resistant subjects (n = 9) matched for weight, body fat, and aerobic fitness were studied before any treatment (B), after 2-3 wk of 2,000 mg/day metformin (MET), and after metformin plus 40 min of exercise at 65% Vo(2peak) (MET + Ex). A second group (n = 7) was studied at baseline and after an identical bout of exercise with no metformin (Ex). Biopsies of the vastus lateralis were taken at B, after MET, immediately after MET + Ex (group 1), or immediately after Ex (group 2). Insulin sensitivity was assessed 4 h postexercise with a euglycemic hyperinsulinemic (40 mU.m(2).min(-1)) clamp enriched with [6,6-(2)H]glucose. Insulin sensitivity was 54% higher after Ex (P < 0.01), but there was no change with Met + Ex. Skeletal muscle AMPKalpha2 activity was elevated threefold (P < 0.01) after Ex, but there was no increase with MET + Ex. These findings suggest that the combination of short-term metformin treatment and an acute bout of exercise does not enhance insulin sensitivity, and the addition of metformin may attenuate the well-documented effects of exercise alone.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.