ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Dynamic expression of axon guidance cues required for optic tract development is controlled by fibroblast growth factor signaling.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 54 citations in OpenAlex.
- Long-range chemical signalling in vivo is regulated by mechanical signals.Nature materials · 2026Article
- Direct and Indirect Downstream Pathways That Regulate Repulsive Guidance Effects of FGF3 on Developing Thalamocortical Axons.International journal of molecular sciences · 2025Article
- Fibroblast growth factor signaling in axons: from development to disease.Cell communication and signaling : CCS · 2023Review
- Review
- Roles of Fibroblast Growth Factors in the Axon Guidance.International journal of molecular sciences · 2023Review
- Differential Eye Expression of Xenopus Acyltransferase Gnpat and Its Biochemical Characterization Shed Light on Lipid-Associated Ocular Pathologies.Investigative ophthalmology & visual science · 2023Article
- Mathematical models of neuronal growth.Biomechanics and modeling in mechanobiology · 2022Review
- Enhanced FGFR3 activity in postmitotic principal neurons during brain development results in cortical dysplasia and axonal tract abnormality.Scientific reports · 2020Article
- Expression of Developmentally Important Axon Guidance Cues in the Adult Optic Chiasm.Investigative ophthalmology & visual science · 2019Article
- Radial glia fibers translate Fgf8 morphogenetic signals to generate a thalamic nuclear complex protomap in the mantle layer.Brain structure & function · 2019Article
- Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring.Molecular cell · 2019Article
- Fibroblast growth factor receptor 1 signaling transcriptionally regulates the axon guidance cue slit1.Cellular and molecular life sciences : CMLS · 2018Article
- Mechanosensing is critical for axon growth in the developing brain.Nature neuroscience · 2016Article
- Defects in the retina of Niemann-pick type C 1 mutant mice.BMC neuroscience · 2014Article
- Wiring the retinal circuits activated by light during early development.Neural development · 2014Article
- Connecting the retina to the brain.ASN neuro · 2014Review
- Coupling of NF-protocadherin signaling to axon guidance by cue-induced translation.Nature neuroscience · 2013Article
- Changes in fibroblast growth factor-2 and FGF receptors in the frog visual system during optic nerve regeneration.Journal of chemical neuroanatomy · 2012Article
- Dynamic responses of Xenopus retinal ganglion cell axon growth cones to netrin-1 as they innervate their in vivo target.Developmental neurobiology · 2012Article
- Receptor complexes for each of the Class 3 Semaphorins.Frontiers in cellular neuroscience · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Axons are guided to their targets by molecular cues expressed in their environment. How is the presence of these cues regulated? Although some evidence indicates that morphogens establish guidance cue expression as part of their role in patterning tissues, an important question is whether morphogens are then required to maintain guidance signals. We found that fibroblast growth factor (FGF) signaling sustains the expression of two guidance cues, semaphorin3A (xsema3A) and slit1 (xslit1), throughout the period of Xenopus optic tract development. With FGF receptor inhibition, xsema3A and xslit1 levels were rapidly diminished, and retinal ganglion cell axons arrested in the mid-diencephalon, before reaching their target. Importantly, direct downregulation of XSema3A and XSlit1 mostly phenocopied this axon guidance defect. Thus, FGFs promote continued presence of specific guidance cues critical for normal optic tract development, suggesting a second later role for morphogens, independent of tissue patterning, in maintaining select cues by acting to regulate their transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.