ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2010
Serotonergic neurons migrate radially through the neuroepithelium by dynamin-mediated somal translocation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 47 citations in OpenAlex.
- An experimental platform for stochastic analyses of single serotonergic fibers in the mouse brain.Frontiers in neuroscience · 2023Article
- Pathophysiological Studies of Monoaminergic Neurotransmission Systems in Valproic Acid-Induced Model of Autism Spectrum Disorder.Biomedicines · 2022Review
- High-resolution spatiotemporal analysis of single serotonergic axons in anFrontiers in neuroscience · 2022Article
- The Role of Chondroitin Sulfate Proteoglycans in Nervous System Development.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2021Review
- Developmental Disruption ofFrontiers in cell and developmental biology · 2021Article
- Serotonergic Axons as Fractional Brownian Motion Paths: Insights Into the Self-Organization of Regional Densities.Frontiers in computational neuroscience · 2020Article
- Morphological and electrophysiological properties of serotonin neurons with NMDA modulation in the mesencephalic locomotor region of neonatal ePet-EYFP mice.Experimental brain research · 2019Article
- Lmx1b is required at multiple stages to build expansive serotonergic axon architectures.eLife · 2019Article
- Serotonin neuron development: shaping molecular and structural identities.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- ATP-Dependent Chromatin Remodeling During Cortical Neurogenesis.Frontiers in neuroscience · 2018Review
- Article
- Cellular architecture and transmitter phenotypes of neurons of the mouse median raphe region.Brain structure & function · 2017Article
- Cadherin-13 Deficiency Increases Dorsal Raphe 5-HT Neuron Density and Prefrontal Cortex Innervation in the Mouse Brain.Frontiers in cellular neuroscience · 2017Article
- Up-regulation of serotonin receptor 2B mRNA and protein in the peri-infarcted area of aged rats and stroke patients.Oncotarget · 2016Article
- Functional Interplay between Dopaminergic and Serotonergic Neuronal Systems during Development and Adulthood.ACS chemical neuroscience · 2015Review
- Contributions of chondroitin sulfate proteoglycans to neurodevelopment, injury, and cancer.Current opinion in neurobiology · 2014Review
- Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system.Behavioural brain research · 2014Article
- Dorsal raphe serotonin neurons in mice: immature hyperexcitability transitions to adult state during first three postnatal weeks suggesting sensitive period for environmental perturbation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Cell biology in neuroscience: mechanisms of cell migration in the nervous system.The Journal of cell biology · 2013Review
- Development of the serotonergic cells in murine raphe nuclei and their relations with rhombomeric domains.Brain structure & function · 2013Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Embryonic CNS neurons can migrate from the ventricular zone to their final destination by radial glial-guided locomotion. Another less appreciated mechanism is somal translocation, where the young neuron maintains its primitive ventricular and pial processes, through which the cell body moves. A major problem in studying translocation has been the identification of neuronal-specific markers that appear in primitive, radially shaped cells. We used enhanced yellow fluorescent protein under control of the Pet-1 enhancer/promoter region (ePet-EYFP), a specific marker of early differentiated serotonergic neurons, to study their migration via immunohistology and time-lapse imaging of living slice cultures. As early as E10.0, ePet-EYFP-expressing neurons were axonless, radially oriented, and spanned the entire neuroepithelium. The soma translocated within the pial process toward the pial surface and could also translocate through its neurites, which sprouted from the pial process. The dynamin inhibitor dynasore significantly reduced translocation velocity, while the nonmuscle myosin II inhibitor blebbistatin and the kinesin inhibitor AMP-PNP had no significant effect. Here we show for the first time that serotonergic neurons migrate by somal translocation mediated, in part, by dynamin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.