ArticleNucleic acids research2010
Genome comparison and context analysis reveals putative mobile forms of restriction-modification systems and related rearrangements.
Article in Nucleic acids research, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
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Who cites it
65 citing papers in PubMed, 88 citations in OpenAlex.
- Biology of host-dependent restriction-modification in prokaryotes.EcoSal Plus · 2025Review
- In silico approaches for discovering microbial antiviral defense systems.Briefings in bioinformatics · 2025Review
- Molecular Characterization of a Restriction Endonuclease PsaI fromInternational journal of molecular sciences · 2025Article
- Insights into Superinfection Immunity Regulation of Xanthomonas axonopodis Filamentous Bacteriophage cf.Current microbiology · 2023Article
- A Survey of Archaeal Restriction-Modification Systems.Microorganisms · 2023Article
- Methylome evolution suggests lineage-dependent selection in the gastric pathogen Helicobacter pylori.Communications biology · 2023Article
- Bacterial DNA methyltransferase: A key to the epigenetic world with lessons learned from proteobacteria.Frontiers in microbiology · 2023Review
- Mining bacterial NGS data vastly expands the complete genomes of temperate phages.NAR genomics and bioinformatics · 2022Article
- A mobile restriction-modification system provides phage defence and resolves an epigenetic conflict with an antagonistic endonuclease.Nucleic acids research · 2022Article
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- Genic Selection Within Prokaryotic Pangenomes.Genome biology and evolution · 2021Review
- Article
- Novel Two-Component System-Like Elements Reveal Functional Domains Associated with Restriction-Modification Systems and paraMORC ATPases in Bacteria.Genome biology and evolution · 2021Article
- High Synteny and Sequence Identity between Genomes ofMicroorganisms · 2020Article
- Genomic dissection of the most prevalent Listeria monocytogenes clone, sequence type ST87, in China.BMC genomics · 2019Article
- Genetic variation regulates the activation and specificity of Restriction-Modification systems in Neisseria gonorrhoeae.Scientific reports · 2019Article
- Transcriptome analyses of cells carrying the Type II Csp231I restriction-modification system reveal cross-talk between two unrelated transcription factors: C protein and the Rac prophage repressor.Nucleic acids research · 2019Article
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- Article
- Evolution of Immune Systems From Viruses and Transposable Elements.Frontiers in microbiology · 2019Review
5 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mobility of restriction-modification (RM) gene complexes and their association with genome rearrangements is a subject of active investigation. Here we conducted systematic genome comparisons and genome context analysis on fully sequenced prokaryotic genomes to detect RM-linked genome rearrangements. RM genes were frequently found to be linked to mobility-related genes such as integrase and transposase homologs. They were flanked by direct and inverted repeats at a significantly high frequency. Insertion by long target duplication was observed for I, II, III and IV restriction types. We found several RM genes flanked by long inverted repeats, some of which had apparently inserted into a genome with a short target duplication. In some cases, only a portion of an apparently complete RM system was flanked by inverted repeats. We also found a unit composed of RM genes and an integrase homolog that integrated into a tRNA gene. An allelic substitution of a Type III system with a linked Type I and IV system pair, and allelic diversity in the putative target recognition domain of Type IIG systems were observed. This study revealed the possible mobility of all types of RM systems, and the diversity in their mobility-related organization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.