ArticleMolecular & cellular proteomics : MCP2010
Mass spectrometric identification of aberrantly glycosylated human apolipoprotein C-III peptides in urine from Schistosoma mansoni-infected individuals.
Article in Molecular & cellular proteomics : MCP, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family.The Journal of biological chemistry · 2018Article
- Targeted Measurements of O- and N-Glycopeptides Show That Proteins in High Density Lipoprotein Particles Are Enriched with Specific Glycosylation Compared to Plasma.Journal of proteome research · 2018Article
- Mass Spectrometric Studies of Apolipoprotein Proteoforms and Their Role in Lipid Metabolism and Type 2 Diabetes.Proteomes · 2017Review
- Mass spectrometric immunoassays for discovery, screening and quantification of clinically relevant proteoforms.Bioanalysis · 2016Review
- Development of multiplex mass spectrometric immunoassay for detection and quantification of apolipoproteins C-I, C-II, C-III and their proteoforms.Methods (San Diego, Calif.) · 2015Article
- A novel secreted metalloprotease (CD2830) from Clostridium difficile cleaves specific proline sequences in LPXTG cell surface proteins.Molecular & cellular proteomics : MCP · 2014Article
- Protein post-translational modifications and regulation of pluripotency in human stem cells.Cell research · 2014Review
- LC-MS/MS identification of the O-glycosylation and hydroxylation of amino acid residues of collagen α-1 (II) chain from bovine cartilage.Journal of proteome research · 2013Article
- Targeting the glycoproteome.Glycoconjugate journal · 2013Article
- Glycomics using mass spectrometry.Glycoconjugate journal · 2013Review
- Longitudinal analysis of maternal plasma apolipoproteins in pregnancy: a targeted proteomics approach.Molecular & cellular proteomics : MCP · 2013Article
- Quantification of glycopeptides by multiple reaction monitoring liquid chromatography/tandem mass spectrometry.Rapid communications in mass spectrometry : RCM · 2012Article
- Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.Molecular & cellular proteomics : MCP · 2012Article
- Specific lectin biomarkers for isolation of human pluripotent stem cells identified through array-based glycomic analysis.Cell research · 2011Article
- Alterations in glycopeptides associated with herceptin treatment of human breast carcinoma mcf-7 and T-lymphoblastoid cells.Molecular & cellular proteomics : MCP · 2011Article
- Improved identification of O-linked glycopeptides from ETD data with optimized scoring for different charge states and cleavage specificities.Amino acids · 2011Article
- Targeted glycoproteomic analysis reveals that kappa-5 is a major, uniquely glycosylated component of Schistosoma mansoni egg antigens.Molecular & cellular proteomics : MCP · 2011Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schistosomiasis is a parasitic infection caused by Schistosoma flatworms, prime examples of multicellular parasites that live in the mammalian host for many years. Glycoconjugates derived from the parasite have been shown to play an important role in many aspects of schistosomiasis, and some of them are present in the circulation of the host. The aim of this study was to identify novel glycoconjugates related to schistosomiasis in urine of Schistosoma mansoni-infected individuals using a combination of glycopeptide separation techniques and in-depth mass spectrometric analysis. Surprisingly, we characterized a heterogeneous population of novel aberrantly O-glycosylated peptides derived from the C terminus of human apolipoprotein C-III (apoC-III) in urine of S. mansoni-infected individuals that were not detected in urine of non-infected controls. The glycan composition of these glycopeptides is completely different from what has been described previously for apoC-III. Most importantly, they lack sialylation and display a high degree of fucosylation. This study exemplifies the potential of mass spectrometry for the identification and characterization of O-glycopeptides without prior knowledge of either the glycan or the peptide sequence. Furthermore, our results indicate for the first time that as a result of S. mansoni infection the glycosylation of a host protein is altered.
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