ReviewHuman reproduction update
Current knowledge of the aetiology of human tubal ectopic pregnancy.
Review in Human reproduction update. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05591599 (Diagnostic Value of Calponin 2 in Identifying Tubal Pregnancies), which is not on this map. Cited by 125 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Diagnostic Value of Calponin 2 in Identifying Tubal Pregnancies
Who cites it
125 citing papers in PubMed, 4 syntheses or guidelines pooled it, 390 citations in OpenAlex.
- Genome-wide association study meta-analysis supports association between MUC1 and ectopic pregnancy.Human reproduction (Oxford, England) · 2023Pooled it
- Exploring the presence of markers of decidualization in the fallopian tubes: a systematic review.Biology of reproduction · 2023Pooled it
- Pooled it
- Tubal ectopic pregnancy.BMJ clinical evidence · 2012Pooled it
- Use of artificial neural network optimization for MHD and non-Newtonian peritoneal Jeffery nanofluid dynamics on female reproductive health.Journal of biological engineering · 2026Article
- From Suspicion to Confirmation: An Original Study on a Complete Diagnostic Pathway for Ectopic Pregnancy.Journal of clinical medicine · 2026Article
- Prevalence, Clinical Profile, and Outcomes of Ectopic Pregnancy at a Teaching Hospital in a Low-Resource Setting, Northern Ethiopia: A 5-Year Retrospective Chart Review.Journal of pregnancy · 2026Article
- Clinical Profile of Ectopic Pregnancy in a Tertiary Care Center: A Five-Year Retrospective Study.JNMA; journal of the Nepal Medical Association · 2026Observational
- After the Shock: Impact of Ectopic Pregnancy on Subsequent Fertility and Parenthood.Biomedicines · 2025Review
- In vivo dynamic imaging reveals the oviduct as a leaky peristaltic pump in transporting a preimplantation embryo toward pregnancy.Biomedical optics express · 2025Article
- Deeper Trophoblastic Invasion and More-Promotive Vascular Remodeling in Tubal Isthmic Pregnancy Compared with Ampullary Pregnancy: A Retrospective Clinicopathological Study.Reproductive sciences (Thousand Oaks, Calif.) · 2025Article
- Establishing a predictive model for ectopic pregnancy risk following assisted reproductive technology.BMC pregnancy and childbirth · 2025Article
- Noncommunicating Fimbrial Ectopic Pregnancy Due to Intraperitoneal Transmigration of Sperm: A Case Report.Cureus · 2025Article
- Exploring the Effects of Oxidative Stress on Female Reproductive Function: The Role of Antioxidant Supplementation.Current drug metabolism · 2025Review
- Labium Majus Ectopic Pregnancy: Diagnostic and Therapeutic Implications of a Rare Obstetric Phenomenon-A Case Report.Case reports in obstetrics and gynecology · 2025Article
- Ipsilateral ectopic pregnancy in the distal remaining part of the previously removed Fallopian tube: a case report.Journal of medical case reports · 2024Article
- Ectopic pregnancy.Nature reviews. Disease primers · 2024Review
- Methotrexate-Induced Toxicity After Ultrasound-Guided Intragestational Injection in a Patient with Caesarean Scar Pregnancy-A Case Report.Medicina (Kaunas, Lithuania) · 2024Article
- Three-dimensional particle streak velocimetry based on optical coherence tomography for assessing preimplantation embryo movement in mouse oviduct in vivo.Biomedical optics express · 2024Article
- Ectopic pregnancy, its potential links to dementia risk and interactions with depression: insights from a nationwide cohort study.Frontiers in psychiatry · 2024Article
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND An ectopic pregnancy is a pregnancy which occurs outside of the uterine cavity, and over 98% implant in the Fallopian tube. Tubal ectopic pregnancy remains the most common cause of maternal mortality in the first trimester of pregnancy. The epidemiological risk factors for tubal ectopic pregnancy are well established and include: tubal damage as a result of surgery or infection (particularly Chlamydia trachomatis), smoking and in vitro fertilization. This review appraises the data to date researching the aetiology of tubal ectopic pregnancy. METHODS Scientific literature was searched for studies investigating the underlying aetiology of tubal ectopic pregnancy. RESULTS Existing data addressing the underlying cause of tubal ectopic pregnancy are mostly descriptive. There are currently few good animal models of tubal ectopic pregnancy. There are limited data explaining the link between risk factors and tubal implantation. CONCLUSIONS Current evidence supports the hypothesis that tubal ectopic pregnancy is caused by a combination of retention of the embryo within the Fallopian tube due to impaired embryo-tubal transport and alterations in the tubal environment allowing early implantation to occur. Future studies are needed that address the functional consequences of infection and smoking on Fallopian tube physiology. A greater understanding of the aetiology of tubal ectopic pregnancy is critical for the development of improved preventative measures, the advancement of diagnostic screening methods and the development of novel treatments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.