ReviewTrends in neurosciences2010
Senescent synapses and hippocampal circuit dynamics.
Review in Trends in neurosciences, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 119 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
119 citing papers in PubMed, 1 synthesis or guideline pooled it, 191 citations in OpenAlex.
- Hippocampus-Related Cognitive and Affective Impairments in Patients With Breast Cancer-A Systematic Review.Frontiers in oncology · 2020Pooled it
- Exercise-Induced Extracellular Vesicle-Associated miRNAs in Cognitive Aging of Older Adults: A Narrative Review.International journal of molecular sciences · 2026Review
- Standardized Extract of Ginkgo biloba L. Reverses Memory Impairment in Older Female Mice with Basal Forebrain Cholinergic Dysfunction.Neurochemical research · 2026Article
- Audiovisual gamma stimulation restores hippocampal neurogenesis and neural circuit plasticity in aging mice.Molecular psychiatry · 2026Article
- Cell-state mapping reveals a reversible neuroblast accumulation in the aging mouse hippocampus.bioRxiv : the preprint server for biology · 2026Article
- Genetic deletion of adenosine AGeroScience · 2026Article
- Peripheral B cell populations tune spontaneous neuronal activity in the uninjured hippocampus after stroke.bioRxiv : the preprint server for biology · 2026Article
- Targeting neuroplasticity in old brain: restoring synapse with cognitive strategies.Biogerontology · 2026Review
- Transcranial Ultrasound Stimulation Pulsed at 40 Hz Improves Cognition and Neuroinflammation in Female Mice with Alzheimer's Disease.Research (Washington, D.C.) · 2026Article
- Rodents' episodic-like memory: concepts, ageing, neurodegeneration, future.Translational neuroscience · 2026Article
- Mapping and modulating brain dynamics in aging and neurodegeneration with electroencephalography and integrated neurotechnologies in primates.Frontiers in neuroscience · 2026Review
- Rice bran extract ameliorate heavy metal mixture induced hippocampal toxicity via inhibiting oxido-inflammatory damages and modulating Hmox-1/BDNF/Occludin/Aβ40/Aβ42 in rats.Toxicology research · 2025Article
- Entorhinal cortex-hippocampal circuit connectivity in health and disease.Frontiers in human neuroscience · 2024Review
- Loose-patch clamp analysis applied to voltage-gated ionic currents following pharmacological ryanodine receptor modulation in murine hippocampal cornu ammonis-1 pyramidal neurons.Frontiers in physiology · 2024Article
- Increase in activin A may counteract decline in synaptic plasticity with age.Frontiers in aging neuroscience · 2024Article
- Delayed formation of neural representations of space in aged mice.Aging cell · 2023Article
- Neuronal Prosurvival Role of Ceramide Synthase 2 by Olidogendrocyte-to-Neuron Extracellular Vesicle Transfer.International journal of molecular sciences · 2023Article
- Delayed formation of neural representations of space in aged mice.bioRxiv : the preprint server for biology · 2023Article
- Neuronal vulnerability to brain aging and neurodegeneration in cognitively impaired marmoset monkeys (Callithrix jacchus).Neurobiology of aging · 2023Article
- Differential vulnerability of the dentate gyrus to tauopathies in dementias.Acta neuropathologica communications · 2023Article
59 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Excitatory synaptic transmission is altered during aging in hippocampal granule cells, and in CA3 and CA1 pyramidal cells. These functional changes contribute to age-associated impairments in experimentally-induced plasticity in each of these primary hippocampal subregions. In CA1, plasticity evoked by stimulation shares common mechanisms with the synaptic modification observed following natural behavior. Aging results in deficits in both artificially- and behaviorally-induced plasticity, and this could in part reflect age-related changes in Ca2+ homeostasis. Other observations, however, suggest that increased intracellular Ca2+ levels are beneficial under some circumstances. This review focuses on age-associated changes in synaptic function, how these alterations might contribute to cognitive decline, and the extent to which altered hippocampal circuit properties are detrimental or reflect compensatory processes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.