ArticleBrain pathology (Zurich, Switzerland)2010
Hypothermia-induced neurite outgrowth is mediated by tumor necrosis factor-alpha.
Article in Brain pathology (Zurich, Switzerland), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 33 citations in OpenAlex.
- The future of artificial hibernation medicine: protection of nerves and organs after spinal cord injury.Neural regeneration research · 2024Review
- Tumor Necrosis Factor α Influences Phenotypic Plasticity and Promotes Epigenetic Changes in Human Basal Forebrain Cholinergic Neuroblasts.International journal of molecular sciences · 2020Article
- Liver Growth Factor Induces Glia-Associated Neuroprotection in an In Vitro Model of Parkinson´s Disease.Brain sciences · 2020Article
- Combined Cyclosporin A and Hypothermia Treatment Inhibits Activation of BV-2 Microglia but Induces an Inflammatory Response in an Ischemia/Reperfusion Hippocampal Slice Culture Model.Frontiers in cellular neuroscience · 2019Article
- Therapeutic Hypothermia and Neuroprotection in Acute Neurological Disease.Current medicinal chemistry · 2019Review
- Neuroprotective and neuroregenerative potential of pharmacologically-induced hypothermia with D-alanine D-leucine enkephalin in brain injury.Neural regeneration research · 2018Review
- Marked expression of TNF receptors in human peritendinous tissues including in nerve fascicles with axonal damage - Studies on tendinopathy and tennis elbow.Journal of musculoskeletal & neuronal interactions · 2017Article
- A Neurologist's Guide to TNF Biology and to the Principles behind the Therapeutic Removal of Excess TNF in Disease.Neural plasticity · 2015Review
- The pro-inflammatory cytokines IL-1β and TNFα are neurotrophic for enteric neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Absence of IL-1β positively affects neurological outcome, lesion development and axonal plasticity after spinal cord injury.Journal of neuroinflammation · 2013Article
- Neuroprotective activity of peripherally administered liver growth factor in a rat model of Parkinson's disease.PloS one · 2013Article
- Influence of therapeutic hypothermia on regeneration after cerebral ischemia.Frontiers of neurology and neuroscience · 2013Review
- Molecular and cellular pathways as a target of therapeutic hypothermia: pharmacological aspect.Current neuropharmacology · 2012Article
- Neuroprotective mechanisms of hypothermia in brain ischaemia.Nature reviews. Neuroscience · 2012Review
- Article
- Interleukin-1 beta and neurotrophin-3 synergistically promote neurite growth in vitro.Journal of neuroinflammation · 2011Article
- Neuroprotective effect of combination therapy of glatiramer acetate and epigallocatechin-3-gallate in neuroinflammation.PloS one · 2011Article
- Hypothermia and brain inflammation after cardiac arrest.Brain circulationReview
- Mild hypothermia enhances regenerative gene expression in late-stage neural precursors.Medicine internationalArticle
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic or brain-selective hypothermia is a well-established method for neuroprotection after brain trauma. There is increasing evidence that hypothermia exerts beneficial effects on the brain and may also support regenerative responses after brain damage. Here, we have investigated whether hypothermia influences neurite outgrowth in vitro via modulation of the post-injury cytokine milieu. Organotypic brain slices were incubated: deep hypothermia (2 h at 17 degrees C), rewarming (2 h up to 37 degrees C), normothermia (20 h at 37 degrees C). Neurite density and cytokine release (IL 1beta, IL-6, IL-10, and TNF-alpha) were investigated after 24 h. For functional analysis mice deficient in NT-3/NT-4 and TNF-alpha as well as the TNF-alpha inhibitor etanercept were used. Hypothermia led to a significant increase of neurite outgrowth, which was independent of neurotrophin signaling. In contrast to other cytokines investigated, TNF-alpha secretion by organotypic brain slices was significantly increased after deep hypothermia. Moreover, hypothermia-induced neurite extension was abolished after administration of the TNF-alpha inhibitor and in TNF-alpha knockout mice. We demonstrate that TNF-alpha is responsible for inducing neurite outgrowth in the context of deep hypothermia and rewarming. These data suggest that hypothermia not only exerts protective effects in the CNS but may also support neurite outgrowth as a potential mechanism of regeneration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.