Evidence map›Paper›PMID 20070198›Full record

ReviewAnnual review of public health2010

The behavioral response to personalized genetic information: will genetic risk profiles motivate individuals and families to choose more healthful behaviors?

Colleen M McBride, Laura M Koehly, Saskia C Sanderson, Kimberly A Kaphingst

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Annual review of public health, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02829138 (Personalized Nutrition in Young Adults), which is not on this map. Cited by 127 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02829138 nacompletednot on this mapstarted 2015, after this paper: background citation

Personalized Nutrition in Young Adults: The Ability of Genetic Information to Motivate Changes in Omega-3 Consumption

TypeinterventionalSponsorUniversity of GuelphRan2015 to 2016Enrolled57ConditionsHealth Behaviour, Nutrition Intervention, Impaired HealthArmsGenetic information and Omega-3 fat intake, General Nutrition related to Omega-3 fats
3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Genetically influenced externalizing and internalizing risk pathways as novel prevention targets.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2022
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  11. Evaluating Approaches for Communication About Genomic Influences on Body Weight.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2015
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  18. Public knowledge of and attitudes toward genetics and genetic testing.Genetic testing and molecular biomarkers · 2013
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  19. Physical activity and differential methylation of breast cancer genes assayed from saliva: a preliminary investigation.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2013
    Trial
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Colleen M McBrideSocial and Behavioral Research Branch, National Human Genome Research Institute, Bethesda, Maryland 20892, USA. cmcbride@mail.nih.gov
Laura M Koehly
Saskia C Sanderson
Kimberly A Kaphingst

Funding

The influence of familial social context on risk dissemination and copingZIAHG200335 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI KOEHLY, LAURA M · 2009 to 2025
$13.6M
Multiplex InitiativeZIAHG200344 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI MC BRIDE, COLLEEN M · 2009 to 2013
$3.9M
6 · The paper itself

Abstract

This report describes the use of information emerging from genetic discovery to motivate risk-reducing health behaviors. Most research to date has evaluated the effects of information related to rare genetic variants on screening behaviors, in which genetic risk feedback has been associated consistently with improved screening adherence. The limited research with common genetic variants suggests that genetic information, when based on single-gene variants with low-risk probabilities, has little impact on behavior. The effect on behavioral outcomes of more realistic testing scenarios in which genetic risk is based on numerous genetic variants is largely unexplored. Little attention has been directed to matching genetic information to the literacy levels of target audiences. Another promising area for research is consideration of using genetic information to identify risk shared within kinship networks and to expand the influence of behavior change beyond the individual.

Indexed as

Health BehaviorMotivationRisk Reduction BehaviorChronic DiseaseCommunicationEvidence-Based PracticeFeeding BehaviorGenetic Predisposition to DiseaseGenome, HumanHealth LiteracyHealth PromotionHumansMass ScreeningNeoplasmsRiskSmoking Cessation

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.