ArticlePsychiatry2009
Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample.
Article in Psychiatry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Posttraumatic stress disorder and tobacco use: A systematic review and meta-analysis.Addictive behaviors · 2018Pooled it
- A coordinate-based meta-analytic model of trauma processing in posttraumatic stress disorder.Human brain mapping · 2013Pooled it
- Association of COMT Val(108/158)Met genotype and cigarette smoking in pregnant women.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2011Pooled it
- Early intervention following trauma may mitigate genetic risk for PTSD in civilians: a pilot prospective emergency department study.The Journal of clinical psychiatry · 2014Trial
- Tobacco use in the context of natural disasters: a scoping review pertinent to tobacco control in Indonesia.BMJ open · 2026Article
- Hyperarousal, Dissociation, Emotion Dysregulation and Re-Experiencing-Towards Understanding Molecular Aspects of PTSD Symptoms.International journal of molecular sciences · 2025Review
- Social support in relation to posttraumatic stress disorder symptoms among patients with violent versus nonviolent injury.Psychological trauma : theory, research, practice and policy · 2024Article
- Hurricane Michael and Adverse Social and Mental Health Risk Factors.Maternal and child health journal · 2023Article
- Smoking cessation among people with mental illness: A South African perspective.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2022Article
- Self-Reported Oil Spill Exposure and Pregnancy Complications: The GROWH Study.International journal of environmental research and public health · 2017Article
- Converging findings from linkage and association analyses on susceptibility genes for smoking and other addictions.Molecular psychiatry · 2016Review
- Post-Traumatic Stress Disorder and Risk for Incident Rheumatoid Arthritis.Arthritis care & research · 2016Observational
- Gene-environment interaction of ApoE genotype and combat exposure on PTSD.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2013Article
- Impact of COMT Val 108/158 Met and DRD2 Taq1B gene polymorphisms on vulnerability to cigarette smoking of Thai males.Journal of molecular neuroscience : MN · 2013Article
- Tobacco addiction and the dysregulation of brain stress systems.Neuroscience and biobehavioral reviews · 2012Review
- Higher FKBP5, COMT, CHRNA5, and CRHR1 allele burdens are associated with PTSD and interact with trauma exposure: implications for neuropsychiatric research and treatment.Neuropsychiatric disease and treatment · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
Tobacco smoking has been found to increase after the experience of a traumatic event and has been associated with posttraumatic stress disorder (PTSD). Initiation and persistence of cigarette smoking is moderately heritable; two recent investigations have implicated the COMT Val158Met (also known as rs4680) polymorphism in smoking age of initiation, dependence, as well as in quantity and frequency of smoking. To examine a possible association of COMT Val158Met and posttrauma increases in cigarette smoking, we studied 614 adults from the 2004 Florida Hurricane Study who returned saliva DNA samples via mail. PTSD was strongly associated with increased smoking. Moreover, each COMT Val158Met 'Met' allele predicted a 2.10-fold risk of smoking post-hurricane, independent of PTSD; follow-up analyses revealed that this finding was primarily driven by European-American males. This study represents the first genetic association study (to our knowledge) of smoking behavior following an acute stressor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.