ArticleDevelopmental and comparative immunology2010
Functional analysis of Rousettus aegyptiacus "signal transducer and activator of transcription 1" (STAT1).
Article in Developmental and comparative immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Disease tolerance as immune defense strategy in bats: One size fits all?PLoS pathogens · 2024Review
- Henipavirus Immune Evasion and Pathogenesis Mechanisms: Lessons Learnt from Natural Infection and Animal Models.Viruses · 2022Review
- Selection and stability validation of reference gene candidates for transcriptional analysis in Rousettus aegyptiacus.Scientific reports · 2021Article
- Article
- Review
- Antiviral immune responses of bats: a review.Zoonoses and public health · 2013Review
- Molecular characterisation of RIG-I-like helicases in the black flying fox, Pteropus alecto.Developmental and comparative immunology · 2012Article
- The role of antigen-presenting cells in filoviral hemorrhagic fever: gaps in current knowledge.Antiviral research · 2012Review
- Interferon production and signaling pathways are antagonized during henipavirus infection of fruit bat cell lines.PloS one · 2011Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bats are now known as the source of several diseases in humans, but few studies regarding immune responses and factors associated with bats have so far been reported. In this study, we focused on STAT1, one of the critical components in interferon (IFN)-signaling and antiviral activity, which is often targeted by viral proteins to reduce antiviral activity and increase viral replication. We found that Rousettus aegyptiacus STAT1 (bat STAT1) is phosphorylatable and translocates to the nucleus when stimulated with human IFN-alpha (hIFN-alpha). Furthermore, phosphorylation of bat STAT1 and inhibition of nuclear translocation was observed in IFN-stimulated cells infected with the HEP-Flury strain of rabies virus, in the same manner as in other mammals. Additionally, quantitative real-time RT-PCR revealed that bat STAT1 mRNA was highly expressed in the liver, while low in muscle and spleen.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.