ArticleNeurogastroenterology and motility2010
Investigation of esophageal sensation and biomechanical properties in functional chest pain.
Article in Neurogastroenterology and motility, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 55 citations in OpenAlex.
- Mechanical experimentation of the gastrointestinal tract: a systematic review.Biomechanics and modeling in mechanobiology · 2024Pooled it
- Lack of correlation between HRM metrics and symptoms during the manometric protocol.The American journal of gastroenterology · 2014Trial
- Ineffective Esophageal Motility and Its Predictors in Gastroesophageal Reflux Disease Patients with Pathologic Acid Exposure Time.Journal of neurogastroenterology and motility · 2026Article
- Characterization of the layer, direction and time-dependent mechanical behaviour of the human oesophagus and the effects of formalin preservation.Journal of the Royal Society, Interface · 2024Article
- Organizing and Developing a GI Motility Lab in Community Practice: Challenges and Rewards.Current gastroenterology reports · 2022Review
- Capsaicin-Sensitive Vagal Afferent Nerve-Mediated Interoceptive Signals in the Esophagus.Molecules (Basel, Switzerland) · 2021Review
- Diagnosis and Management of Functional Chest Pain in the Rome IV Era.Journal of neurogastroenterology and motility · 2019Review
- The role of oesophageal physiological testing in the assessment of noncardiac chest pain.Therapeutic advances in chronic disease · 2018Review
- Can Acute Stress Cause Esophageal Hypersensitivity in Healthy Individuals?Journal of neurogastroenterology and motility · 2017Article
- Temporal and spectral properties of esophageal mucosal blood perfusion: a comparison between normal subjects and nutcracker esophagus patients.Neurogastroenterology and motility · 2017Article
- How to Diagnose and Treat Functional Chest Pain.Current treatment options in gastroenterology · 2016Review
- Functional lumen imaging probe: The FLIP side of esophageal disease.Current opinion in gastroenterology · 2016Review
- Feasibility and acceptability of esophageal-directed hypnotherapy for functional heartburn.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2016Article
- Mechanisms of the adenosine A2A receptor-induced sensitization of esophageal C fibers.American journal of physiology. Gastrointestinal and liver physiology · 2016Article
- Hypnotherapy for Esophageal Disorders.The American journal of clinical hypnosis · 2015Article
- Abnormal sensory perception or peristaltic dysfunction: which one is associated with symptoms?Journal of neurogastroenterology and motility · 2014Article
- Gastroesophageal reflux symptoms not responding to proton pump inhibitor: GERD, NERD, NARD, esophageal hypersensitivity or dyspepsia?Canadian journal of gastroenterology & hepatology · 2014Article
- Advances in motility testing--current and novel approaches.Nature reviews. Gastroenterology & hepatology · 2013Review
- Diagnostic utility of the oesophageal balloon distension test in the evaluation of oesophageal chest pain.Alimentary pharmacology & therapeutics · 2012Article
- Noncardiac chest pain: epidemiology, natural course and pathogenesis.Journal of neurogastroenterology and motility · 2011Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundThere is limited and conflicting data regarding the role of esophageal hypersensitivity in the pathogenesis of functional chest pain (FCP). We examined esophageal sensori-motor properties, mechanics, and symptoms in subjects with FCP.
methodsEsophageal balloon distension test was performed using impedance planimetry in 189 (m/f = 57/132) consecutive subjects with non-cardiac, non-reflux chest pain, and 36 (m/f = 16/20) healthy controls. The biomechanical and sensory properties of subjects with and without esophageal hypersensitivity were compared with controls. The frequency, intensity, and duration of chest pain were assessed. KEY
resultsOne hundred and forty-three (75%) subjects had esophageal hypersensitivity and 46 (25%) had normal sensitivity. Typical chest pain was reproduced in 105/143 (74%) subjects. Subjects with hypersensitivity demonstrated larger cross-sectional area (P < 0.001), decreased esophageal wall strain (P < 0.001) and distensibility (P < 0.001), and lower thresholds for perception (P < 0.01), discomfort (P < 0.01), and pain (P < 0.01) compared to those without hypersensitivity or healthy controls. Chest pain scores (mean +/- SD) for frequency, intensity and duration were 2.5 +/- 0.3, 2.2 +/- 0.2, and 2.2 +/- 0.2, respectively, and were similar between the two patient groups. CONCLUSIONS & INFERENCES: Seventy-five per cent of subjects with FCP demonstrate esophageal hypersensitivity. Visceral hyperalgesia and sensori-motor dysfunction of the esophagus play a key role in the pathogenesis of chest pain.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.