ArticleMolecular and cellular biochemistry2010
ErbB4 signals Neuregulin1-stimulated cell proliferation and c-fos gene expression through phosphorylation of serum response factor by mitogen-activated protein kinase cascade.
Article in Molecular and cellular biochemistry, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Article
- Elucidating the Pivotal Neuroprotective Mechanisms and Therapeutic Variants of Erythropoietin in Neonatal Brain Injury.Current topics in medicinal chemistry · 2025Review
- The multifaceted role of kinases in amyotrophic lateral sclerosis: genetic, pathological and therapeutic implications.Brain : a journal of neurology · 2020Review
- Benzydamine inhibits osteoclast differentiation and bone resorptionActa pharmaceutica Sinica. B · 2020Article
- Immediate Early Genes Anchor a Biological Pathway of Proteins Required for Memory Formation, Long-Term Depression and Risk for Schizophrenia.Frontiers in behavioral neuroscience · 2018Article
- Erythropoietin Restores Long-Term Neurocognitive Function Involving Mechanisms of Neuronal Plasticity in a Model of Hyperoxia-Induced Preterm Brain Injury.Oxidative medicine and cellular longevity · 2016Article
- Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitive impairment induced by isoflurane in aged mice.Anesthesiology · 2014Article
- The interaction of the ErbB4 intracellular domain p80 with α-enolase in the nuclei is associated with the inhibition of the neuregulin1-dependent cell proliferation.International journal of biochemistry and molecular biology · 2014Article
- Downregulation of neuregulin 1-ErbB4 signaling in parvalbumin interneurons in the rat brain may contribute to the antidepressant properties of ketamine.Journal of molecular neuroscience : MN · 2014Article
- Regulation of c-Fos gene expression by NF-κB: a p65 homodimer binding site in mouse embryonic fibroblasts but not human HEK293 cells.PloS one · 2013Article
- Neuregulin-1 suppresses cardiomyocyte apoptosis by activating PI3K/Akt and inhibiting mitochondrial permeability transition pore.Molecular and cellular biochemistry · 2012Article
- Effects of A-CREB, a dominant negative inhibitor of CREB, on the expression of c-fos and other immediate early genes in the rat SON during hyperosmotic stimulation in vivo.Brain research · 2012Article
- Subchronic peripheral neuregulin-1 increases ventral hippocampal neurogenesis and induces antidepressant-like effects.PloS one · 2011Article
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Authors and funding
4 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The ErbB family of tyrosine kinase receptors mediates a variety of cellular responses to Neuregulin (NRG) 1; however, the intracellular signaling pathways downstream of ErbB4 and their functional outcomes remained to be elucidated. Here we show that NRG1 stimulated the proliferation of human HeLa cells expressing ErbB4, where the phosphorylation relay of extracellular signal-regulated kinase, a mitogen-activated protein kinase (MAPK), and serum response factor (SRF), a transcription factor, was induced, and the c-fos transcription was activated. By contrast, these all were attenuated in cells transfected with an ErbB4 mutant substituting the green fluorescence protein for the intracellular domain. We also demonstrated that a MAPK kinase inhibitor suppressed the NRG1-stimulated SRF phosphorylation, c-fos expression, and cell proliferation. Thus, the current study may unravel an ErbB4-mediated signaling pathway that is responsible for the NRG1-induced c-fos gene expression through the MAPK cascade-dependent SRF phosphorylation and thereby cell proliferation.
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