Evidence map›Paper›PMID 20066242›Full record

ArticleLab on a chip2010

Counting single molecules in sub-nanolitre droplets.

T D Rane, C M Puleo, K J Liu, Y Zhang, A P Lee, T H Wang

Erratum issuedAbstract readEvaluation Study
In one paragraph

Article in Lab on a chip, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Real-time optical spectroscopy forNanoscale advances · 2026
    Article
  2. Breakdown of Langmuir Adsorption Isotherm in Small Closed Systems.Langmuir : the ACS journal of surfaces and colloids · 2024
    Article
  3. Droplet microfluidics for high-sensitivity and high-throughput detection and screening of disease biomarkers.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology · 2018
    Review
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4 · The record

Corrections and comments

  • Erratum issued
5 · Who and what money

Authors and funding

6 authors.

T D RaneJohns Hopkins University, Department of Biomedical Engineering, 3400 N. Charles St., Clark Hall, Baltimore, MD, USA. tushar@jhu.edu
C M Puleo
K J Liu
Y Zhang
A P Lee
T H Wang

Funding

Vaccine strategy for broad spectrum protection agains non-typhoidal salmonellU54AI057168 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ROTHMAN, RICHARD E · 2003 to 2013
$91.5M
Nanobiosensing Method for Point Mutation Detection of CancerR21CA120742 · NCI · JOHNS HOPKINS UNIVERSITY · PI WANG, TZA-HUEI JEFF · 2008 to 2009
$387k
NCI NIH HHS 1R21CA120742-01NCI NIH HHS R21 CA120742NIAID NIH HHS U54 AI057168
6 · The paper itself

Abstract

We demonstrate single biomolecule detection and quantification within sub-nanolitre droplets through application of Cylindrical Illumination Confocal Spectroscopy (CICS) and droplet confinement within a retractable microfluidic constriction.

Indexed as

DNAEquipment DesignEquipment Failure AnalysisMicrofluidic Analytical TechniquesMicroscopy, ConfocalNanostructuresNanotechnologyParticle SizeReproducibility of ResultsSensitivity and SpecificitySolutionsSpectrometry, FluorescenceDNASolutions

Identifiers

PMID20066242
PMCPMC3000353

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.