Evidence map›Paper›PMID 20066108›Full record

ReviewCold Spring Harbor perspectives in biology2009

Planar cell polarity signaling: the developing cell's compass.

Eszter K Vladar, Dragana Antic, Jeffrey D Axelrod

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 237 citations in OpenAlex.

  1. Article
  2. Article
  3. Integrative Analysis of Key Signalling Pathways in Neural Tube Defects: From Molecular Mechanisms to Therapeutic Strategies.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2025
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Nutrient sensitive proteinLife science alliance · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Regulation of Cell Polarity by Posttranslational Protein Palmitoylation.Methods in molecular biology (Clifton, N.J.) · 2022
    Article
  19. Article
  20. Article

80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Eszter K VladarDepartment of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305, USA.
Dragana Antic
Jeffrey D Axelrod
Stanford University · US

Funding

TUMOR BIOLOGYT32CA009151 · NCI · STANFORD UNIVERSITY · PI CLEARY, MICHAEL L · 1985 to 2014
$5.5M
SIGNALING MECHANISMS CONTROLLING PLANAR CELL POLARITYR01GM059823 · NIGMS · STANFORD UNIVERSITY · PI AXELROD, JEFFREY D. · 2000 to 2013
$4.1M
NCI NIH HHS T32 CA009151NIGMS NIH HHS R01 GM059823
6 · The paper itself

Abstract

Cells of many tissues acquire cellular asymmetry to execute their physiologic functions. The planar cell polarity system, first characterized in Drosophila, is important for many of these events. Studies in Drosophila suggest that an upstream system breaks cellular symmetry by converting tissue gradients to subcellular asymmetry, whereas a downstream system amplifies subcellular asymmetry and communicates polarity between cells. In this review, we discuss apparent similarities and differences in the mechanism that controls PCP as it has been adapted to a broad variety of morphological cellular asymmetries in various organisms.

Indexed as

Cell PolaritySignal TransductionAnimalsBody PatterningCell DivisionCell MovementCiliaCytoskeletonDevelopmental BiologyDrosophilaHumansMiceModels, BiologicalModels, GeneticMutation

Identifiers

PMID20066108
PMCPMC2773631
OpenAlexW2120032068

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.