ReviewCold Spring Harbor perspectives in biology2009
Physical model of cellular symmetry breaking.
Review in Cold Spring Harbor perspectives in biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
10 citing papers in PubMed, 37 citations in OpenAlex.
- Synthetic control of actin polymerization and symmetry breaking in active protocells.Science advances · 2024Article
- Balance between cell-substrate adhesion and myosin contraction determines the frequency of motility initiation in fish keratocytes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- Asymmetric ligand binding facilitates conformational transitions in pentameric ligand-gated ion channels.Journal of the American Chemical Society · 2013Article
- Reconstruction of active regular motion in amoeba extract: dynamic cooperation between sol and gel states.PloS one · 2013Article
- Weakly nonlinear analysis of symmetry breaking in cell polarity models.Physical biology · 2012Article
- Scared stiff: Stabilizing the actin cytoskeleton to stop invading cancer cells in their tracks.Bioarchitecture · 2011Article
- Symmetry breaking in biology.Cold Spring Harbor perspectives in biology · 2010Review
- Cytoskeletal mechanisms for breaking cellular symmetry.Cold Spring Harbor perspectives in biology · 2010Review
- Cellular symmetry breaking during Caenorhabditis elegans development.Cold Spring Harbor perspectives in biology · 2009Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cells can polarize in response to external signals, such as chemical gradients, cell-cell contacts, and electromagnetic fields. However, cells can also polarize in the absence of an external cue. For example, a motile cell, which initially has a more or less round shape, can lose its symmetry spontaneously even in a homogeneous environment and start moving in random directions. One of the principal determinants of cell polarity is the cortical actin network that underlies the plasma membrane. Tension in this network generated by myosin motors can be relaxed by rupture of the shell, leading to polarization. In this article, we discuss how simplified model systems can help us to understand the physics that underlie the mechanics of symmetry breaking.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.