ArticlePLoS genetics2010
Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels.
Article in PLoS genetics, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Identification of genetic variants influencing the human plasma proteome.Proceedings of the National Academy of Sciences of the United States of America · 2013Trial
- Trial
- A Potential Role for MAGI-1 in the Bi-Directional Relationship Between Major Depressive Disorder and Cardiovascular Disease.Current atherosclerosis reports · 2024Review
- Identification and Diagnosis of Complete Haptoglobin Gene Deletion, One of the Genes Responsible for Adverse Posttransfusion Reactions.Biomedicines · 2024Review
- The role of GLUT2 in glucose metabolism in multiple organs and tissues.Molecular biology reports · 2023Review
- Using transects to disentangle the environmental drivers of plant-microbiome assembly.Plant, cell & environment · 2021Article
- Haptoglobin polymorphisms in Latin American populations.Scientific reports · 2020Article
- Review
- Haptoglobin Hp1 Variant Does Not Associate with Small Vessel Disease.Brain sciences · 2019Article
- Allelic Variation in Taste Genes Is Associated with Taste and Diet Preferences and Dental Caries.Nutrients · 2019Article
- Relationship between CETP gene polymorphisms with coronary artery disease in Polish population.Molecular biology reports · 2018Article
- Transdisciplinary approaches enhance the production of translational knowledge.Translational research : the journal of laboratory and clinical medicine · 2017Review
- Comparing GWAS Results of Complex Traits Using Full Genetic Model and Additive Models for Revealing Genetic Architecture.Scientific reports · 2017Article
- Genetic variations of cholesteryl ester transfer protein and diet interactions in relation to lipid profiles and coronary heart disease: a systematic review.Nutrition & metabolism · 2017Review
- A novel interaction between the FLJ33534 locus and smoking in obesity: a genome-wide study of 14 131 Pakistani adults.International journal of obesity (2005) · 2016Article
- GLUT2, glucose sensing and glucose homeostasis.Diabetologia · 2015Review
- Association between CETP, MLXIPL, and TOMM40 polymorphisms and serum lipid levels in a Latvian population.Meta gene · 2014Article
- Genome-wide association study of Arabidopsis thaliana leaf microbial community.Nature communications · 2014Article
- IgA measurements in over 12 000 Swedish twins reveal sex differential heritability and regulatory locus near CD30L.Human molecular genetics · 2014Article
- Future of biobanks - bigger, longer, and more dimensional.Croatian medical journal · 2013Article
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Authors and funding
21 authors.
Funding
Abstract
Genome-wide association studies (GWAS) have identified 38 larger genetic regions affecting classical blood lipid levels without adjusting for important environmental influences. We modeled diet and physical activity in a GWAS in order to identify novel loci affecting total cholesterol, LDL cholesterol, HDL cholesterol, and triglyceride levels. The Swedish (SE) EUROSPAN cohort (N(SE) = 656) was screened for candidate genes and the non-Swedish (NS) EUROSPAN cohorts (N(NS) = 3,282) were used for replication. In total, 3 SNPs were associated in the Swedish sample and were replicated in the non-Swedish cohorts. While SNP rs1532624 was a replication of the previously published association between CETP and HDL cholesterol, the other two were novel findings. For the latter SNPs, the p-value for association was substantially improved by inclusion of environmental covariates: SNP rs5400 (p(SE,unadjusted) = 3.6 x 10(-5), p(SE,adjusted) = 2.2 x 10(-6), p(NS,unadjusted) = 0.047) in the SLC2A2 (Glucose transporter type 2) and rs2000999 (p(SE,unadjusted) = 1.1 x 10(-3), p(SE,adjusted) = 3.8 x 10(-4), p(NS,unadjusted) = 0.035) in the HP gene (Haptoglobin-related protein precursor). Both showed evidence of association with total cholesterol. These results demonstrate that inclusion of important environmental factors in the analysis model can reveal new genetic susceptibility loci.
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