SynthesisAnnals of family medicine
Safety and efficacy of nontherapeutic male circumcision: a systematic review.
Synthesis in Annals of family medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Trial
- Efficiency and Patient Satisfaction of Local Anesthesia Use in Surgical Circumcision in Adults-A Retrospective Cohort Study.BioMed research international · 2026Article
- Article
- Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (full version).Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Canadian Urological Association guideline on the care of the normal foreskin and neonatal circumcision in Canadian infants (abridged version).Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2018Article
- Circumcision in hemophilia using low quantity of factor concentrates: experience from Dakar, Senegal.BMC hematology · 2017Article
- Health service provider education and/or training in infant male circumcision to improve short- and long-term morbidity outcomes: protocol for systematic review.Systematic reviews · 2016Article
- Social representations of male circumcision as prophylaxis against HIV/AIDS in Zimbabwe.BMC public health · 2015Article
- Diagnostic evaluation of our patients with hemophilia A: 17-year experience.Turk pediatri arsivi · 2015Article
- Feasibility and validity of telephone triage for adverse events during a voluntary medical male circumcision campaign in Swaziland.BMC public health · 2014Article
- Non-therapeutic male circumcision performed on immigrant children from Africa in Spain.International journal of public health · 2014Article
- Mass safe male circumcision: early lessons from a Ugandan urban site - a case study.The Pan African medical journal · 2012Article
- Routine peripubertal circumcision?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2011Article
- Determination and evaluation of HR-HPV genotype in different communities of Bihar, India.International journal of health sciencesArticle
- Male circumcision performed with 8-figure non-absorbable suture technique.Canadian Urological Association journal = Journal de l'Association des urologues du CanadaArticle
- In this issue:race, place, and sex matter.Annals of family medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe wanted to assess the safety and efficacy of nontherapeutic male circumcision through a systematic review of the literature.
methodsWe systematically searched The York Centre for Reviews and Disseminations, Cochrane Library, PubMed, and EMBASE databases for randomized controlled trials published between January 1997 and August 2008. Studies reporting on circumcision in an operative setting in males of any age with no contraindications to or medical indications for circumcision were eligible for inclusion. The main comparator was intact genitalia. From 73 retrieved studies, 8 randomized controlled trials were ultimately included for analysis.
resultsSevere complications were uncommon. Analgesia/anesthesia during circumcision was promoted. The prevalence of self-reported genital ulcers was significantly lower in circumcised men than uncircumcised men (3.1% vs 5.8%; prevalence risk ratio 0.53; 95% confidence interval [CI], 0.43-0.64; P<.001). Circumcised sub-Saharan African men were at significantly lower risk of acquiring human immunodeficiency virus/acquired immune deficiency syndrome than were uncircumcised men (random effects odds ratio = 0.44, 95% CI, 0.32-0.59; P <.001). The evidence suggests that adult circumcision does not affect sexual satisfaction and function.
conclusionsStrong evidence suggests circumcision can prevent human immunodeficiency virus/acquired immune deficiency syndrome acquisition in sub-Saharan African men. These findings remain uncertain in men residing in other countries. The role of adult nontherapeutic male circumcision in preventing sexually transmitted infections, urinary tract infections, and penile cancer remains unclear. Current evidence fails to recommend widespread neonatal circumcision for these purposes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.