ArticleJournal of immunology (Baltimore, Md. : 1950)2010
Urine proteome scans uncover total urinary protease, prostaglandin D synthase, serum amyloid P, and superoxide dismutase as potential markers of lupus nephritis.
Article in Journal of immunology (Baltimore, Md. : 1950), 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Biomarkers of systemic lupus erythematosus identified using mass spectrometry-based proteomics: a systematic review.Journal of cellular and molecular medicine · 2017Pooled it
- Article
- Discovery of Novel Circulating Immune Complexes in Lupus Nephritis Using Immunoproteomics.Frontiers in immunology · 2022Article
- Identification of polo-like kinase 1 as a therapeutic target in murine lupus.Clinical & translational immunology · 2022Article
- Curcumin Attenuates Both Acute and Chronic Immune Nephritis.International journal of molecular sciences · 2020Article
- Analysis of expression levels of IL-17 and IL-34 and influencing factors for prognosis in patients with lupus nephritis.Experimental and therapeutic medicine · 2019Article
- iRhom2 promotes lupus nephritis through TNF-α and EGFR signaling.The Journal of clinical investigation · 2018Article
- Urinary haptoglobin, alpha-1 anti-chymotrypsin and retinol binding protein identified by proteomics as potential biomarkers for lupus nephritis.Clinical and experimental immunology · 2017Article
- Urinary β-trace protein: A unique biomarker to screen early glomerular filtration rate impairment.Medicine · 2016Article
- Urine biomarkers in renal allograft.Journal of translational internal medicine · 2016Article
- Article
- Biomarkers for interstitial cystitis/painful bladder syndrome.Women's health (London, England) · 2016Article
- Reagent- and separation-free measurements of urine creatinine concentration using stamping surface enhanced Raman scattering (S-SERS).Biomedical optics express · 2015Article
- Urinary angiostatin--a novel putative marker of renal pathology chronicity in lupus nephritis.Molecular & cellular proteomics : MCP · 2013Article
- Inhibition of the TWEAK/Fn14 pathway attenuates renal disease in nephrotoxic serum nephritis.Clinical immunology (Orlando, Fla.) · 2012Article
- Coupling of epithelial Na+ and Cl- channels by direct and indirect activation by serine proteases.American journal of physiology. Cell physiology · 2012Article
- Association of noninvasively measured renal protein biomarkers with histologic features of lupus nephritis.Arthritis and rheumatism · 2012Article
- Chitinase-like proteins are candidate biomarkers for sepsis-induced acute kidney injury.Molecular & cellular proteomics : MCP · 2012Article
- Urinary biomarkers in lupus nephritis.Clinical reviews in allergy & immunology · 2011Review
- Proteomics in rheumatology: the dawn of a new era.F1000 medicine reports · 2010Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
To identify potential biomarkers in immune-mediated nephritis, urine from mice subjected to an augmented passive model of anti-glomerular basement membrane (GBM)-induced experimental nephritis was resolved using two-dimensional gels. The urinary proteome in these diseased mice was comprised of at least 71 different proteins. Using orthogonal assays, several of these molecules, including serum amyloid P (SAP), PG D synthase, superoxide dismutase, renin, and total protease were validated to be elevated in the urine and kidneys of mice during anti-GBM disease, as well as in mice with spontaneously arising lupus nephritis. Among these, urinary protease was the only marker that appeared to be exclusively renal in origin, whereas the others were partly serum-derived. Longitudinal studies in murine lupus demonstrated that total urinary protease had better predictive value for histologically active nephritis (r = 0.78) compared with proteinuria (r = -0.04), azotemia (r = 0.28), or the other markers examined, whereas urine SAP emerged as the single most predictive marker of histological glomerulonephritis. Collectively, these studies uncover total urinary protease, PG D synthase, SAP, and superoxide dismutase as novel biomarkers of anti-GBM disease and lupus nephritis, with stronger correlation to renal disease compared with currently employed biomarkers. These findings could have important diagnostic and prognostic ramifications in the management of these renal diatheses.
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Registered trials
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