ArticleAntimicrobial agents and chemotherapy2010
Penicillin-binding protein gene alterations in Streptococcus uberis isolates presenting decreased susceptibility to penicillin.
Article in Antimicrobial agents and chemotherapy, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Mastitis-Associated Bacterial Isolates and Antimicrobial Resistance in a Single Dairy Herd in the Akmola Region, Kazakhstan.Antibiotics (Basel, Switzerland) · 2026Article
- Antibiotic susceptibility of mastitis pathogens in Finnish dairy cows in 2022-2023: concerning changes in the penicillin susceptibility of Streptococcus uberis.Acta veterinaria Scandinavica · 2026Article
- Global analysis of the genomic diversity, antimicrobial resistance and potential vaccine candidates carried by the major global bovine pathogenMicrobial genomics · 2025Article
- Whole-genome sequencing ofJournal of medical microbiology · 2024Article
- Comparison of Minimum Inhibitory Concentrations of Selected Antimicrobials for Non-AureusAntibiotics (Basel, Switzerland) · 2024Article
- Fructose promotes ampicillin killing of antibiotic-resistantVirulence · 2023Article
- Antimicrobial Susceptibility and Resistance Genes inAntibiotics (Basel, Switzerland) · 2023Article
- Therapy of Subclinical Mastitis during Lactation.Antibiotics (Basel, Switzerland) · 2022Article
- Large-scale genomic analysis of antimicrobial resistance in the zoonotic pathogen Streptococcus suis.BMC biology · 2021Article
- Microbial Aetiology, Antibiotic Susceptibility and Pathogen-Specific Risk Factors for Udder Pathogens from Clinical Mastitis in Dairy Cows.Animals : an open access journal from MDPI · 2021Article
- EnvironmentalAnimals : an open access journal from MDPI · 2021Article
- Genotyping and Antimicrobial Susceptibility Profiling ofAntibiotics (Basel, Switzerland) · 2021Article
- A Single Amino Acid Replacement in Penicillin-Binding Protein 2X in Streptococcus pyogenes Significantly Increases Fitness on Subtherapeutic Benzylpenicillin Treatment in a Mouse Model of Necrotizing Myositis.The American journal of pathology · 2020Article
- Molecular variability ofCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2019Article
- Fluoroquinolone-derived fluorescent probes for studies of bacterial penetration and efflux.MedChemComm · 2019Article
- Genotyping and antimicrobial resistance of Streptococcus uberis isolated from bovine clinical mastitis.PloS one · 2019Article
- Antimicrobial Resistance inMicrobiology spectrum · 2018Review
- Differential Ability of Bovine Antimicrobial Cathelicidins to Mediate Nucleic Acid Sensing by Epithelial Cells.Frontiers in immunology · 2017Article
- Antimicrobial Susceptibility Patterns of Environmental Streptococci Recovered from Bovine Milk Samples in the Maritime Provinces of Canada.Frontiers in veterinary science · 2016Article
- Comment on "Intravitreal Ampicillin Sodium for Antibiotic-Resistant Endophthalmitis: Streptococcus uberis First Human Intraocular Infection Report".Journal of ophthalmology · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptococcus uberis is an environmental pathogen commonly causing bovine mastitis, an infection that is generally treated with penicillin G. No field case of true penicillin-resistant S. uberis (MIC > 16 mg/liter) has been described yet, but isolates presenting decreased susceptibility (MIC of 0.25 to 0.5 mg/liter) to this drug are regularly reported to our laboratory. In this study, we demonstrated that S. uberis can readily develop penicillin resistance in laboratory-evolved mutants. The molecular mechanism of resistance (acquisition of mutations in penicillin-binding protein 1A [PBP1A], PBP2B, and PBP2X) was generally similar to that of all other penicillin-resistant streptococci described so far. In addition, it was also specific to S. uberis in that independent resistant mutants carried a unique set of seven consensus mutations, of which only one (Q(554)E in PBP2X) was commonly found in other streptococci. In parallel, independent isolates from bovine mastitis with different geographical origins (France, Holland, and Switzerland) and presenting a decreased susceptibility to penicillin were characterized. No mosaic PBPs were detected, but they all presented mutations identical to the one found in the laboratory-evolved mutants. This indicates that penicillin resistance development in S. uberis might follow a stringent pathway that would explain, in addition to the ecological niche of this pathogen, why naturally occurring resistances are still rare. In addition, this study shows that there is a reservoir of mutated PBPs in animals, which might be exchanged with other streptococci, such as Streptococcus agalactiae, that could potentially be transmitted to humans.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.