ArticleInfection and immunity2010
Identification of a c-di-GMP-regulated polysaccharide locus governing stress resistance and biofilm and rugose colony formation in Vibrio vulnificus.
Article in Infection and immunity, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 45 citations in OpenAlex.
- The diguanylate cyclase and phosphodiesterase locally regulate the virulence factors in Vibrio vulnificus.Gut pathogens · 2025Article
- Spatio-genetically coordinated TPR domain-containing proteins modulate c-di-GMP signaling in Vibrio vulnificus.PLoS pathogens · 2025Article
- Stress adaptation underMicrobiology spectrum · 2025Article
- Discovery of a Small-Molecule Inhibitor Targeting the Biofilm Regulator BrpT inJournal of microbiology and biotechnology · 2024Article
- Identification and characterization of a small molecule BFstatin inhibiting BrpR, the transcriptional regulator for biofilm formation ofFrontiers in microbiology · 2024Article
- Two novel genes identified by large-scale transcriptomic analysis are essential for biofilm and rugose colony development of Vibrio vulnificus.PLoS pathogens · 2023Article
- A Master Regulator BrpR Coordinates the Expression of Multiple Loci for Robust Biofilm and Rugose Colony Development inFrontiers in microbiology · 2021Article
- Structure, Function, and Regulation of the Essential Virulence Factor Capsular Polysaccharide ofInternational journal of molecular sciences · 2020Review
- A Regulatory Network ControlsFrontiers in microbiology · 2019Article
- Article
- Complex Control of a Genomic Island Governing Biofilm and Rugose Colony Development in Vibrio vulnificus.Journal of bacteriology · 2018Article
- A Tad pilus promotes the establishment and resistance ofNPJ biofilms and microbiomes · 2018Article
- The Proline Variant of the W[F/L/M][T/S]R Cyclic Di-GMP Binding Motif Suppresses Dependence on Signal Association for Regulator Function.Journal of bacteriology · 2017Article
- The cabABC Operon Essential for Biofilm and Rugose Colony Development in Vibrio vulnificus.PLoS pathogens · 2015Article
- There and back again: consequences of biofilm specialization under selection for dispersal.Frontiers in genetics · 2015Article
- Genome-wide evaluation of the interplay between Caenorhabditis elegans and Yersinia pseudotuberculosis during in vivo biofilm formation.Infection and immunity · 2015Article
- Article
- Genetic analysis and prevalence studies of the brp exopolysaccharide locus of Vibrio vulnificus.PloS one · 2014Article
- LuxR homologue SmcR is essential for Vibrio vulnificus pathogenesis and biofilm detachment, and its expression is induced by host cells.Infection and immunity · 2013Article
- Fitness factors in vibrios: a mini-review.Microbial ecology · 2013Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
As an etiological agent of bacterial sepsis and wound infections, Vibrio vulnificus is unique among the Vibrionaceae. Its continued environmental persistence and transmission are bolstered by its ability to colonize shellfish, form biofilms on various marine biotic surfaces, and generate a morphologically and physiologically distinct rugose (R) variant that yields profuse biofilms. Here, we identify a c-di-GMP-regulated locus (brp, for biofilm and rugose polysaccharide) and two transcription factors (BrpR and BrpT) that regulate these physiological responses. Disruption of glycosyltransferases within the locus or either regulator abated the inducing effect of c-di-GMP on biofilm formation, rugosity, and stress resistance. The same lesions, or depletion of intracellular c-di-GMP levels, abrogated these phenotypes in the R variant. The parental and brp mutant strains formed only scant monolayers on glass surfaces and oyster shells, and although the R variant formed expansive biofilms, these were of limited depth. Dramatic vertical expansion of the biofilm structure was observed in the parental strain and R variant, but not the brp mutants, when intracellular c-di-GMP levels were elevated. Hence, the brp-encoded polysaccharide is important for surface colonization and stress resistance in V. vulnificus, and its expression may control how the bacteria switch from a planktonic lifestyle to colonizing shellfish to invading human tissue.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.