ArticleThe American journal of tropical medicine and hygiene2010
Association between mannose-binding lectin polymorphisms and Wuchereria bancrofti infection in two communities in North-Eastern Tanzania.
Article in The American journal of tropical medicine and hygiene, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Prevalence of elephantiasis, an overlooked disease in Southern Africa: a comprehensive review.The journal of venomous animals and toxins including tropical diseases · 2024Review
- Duplication mutation in CHIT1 gene is associated with poor response to medical therapy in patients affected with filarial chyluria.Bioinformation · 2020Article
- The Genetic Polymorphisms of 24 Base Pair Duplication and Point G102S of Human Chitotriosidase to Bancroftian Filariasis at the Thai⁻Myanmar Border.Pathogens (Basel, Switzerland) · 2019Article
- Genetic association of MBL-2 gene polymorphisms with Filarial chyluria.Bioinformation · 2019Article
- Genetic and Phenotypic Screening of Mannose-Binding Lectin in Relation to Risk of Recurrent Vulvovaginal Infections in Women of North India: A Prospective Cohort Study.Frontiers in microbiology · 2017Article
- A comprehensive in silico analysis of non-synonymous and regulatory SNPs of human MBL2 gene.SpringerPlus · 2016Article
- Particularities of allergy in the Tropics.The World Allergy Organization journal · 2016Review
- MBL-2 polymorphisms (codon 54 and Y-221X) and low MBL levels are associated with susceptibility to multi organ dysfunction in P. falciparum malaria in Odisha, India.Frontiers in microbiology · 2015Article
- Immunopathogenesis of lymphatic filarial disease.Seminars in immunopathology · 2012Review
- Heightened measures of immune complex and complement function and immune complex-mediated granulocyte activation in human lymphatic filariasis.The American journal of tropical medicine and hygiene · 2011Article
- Association between Toll-like receptor 2 (TLR2) polymorphisms and asymptomatic bancroftian filariasis.Parasitology research · 2010Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The association between selected mannose-binding lectin (MBL) genotype polymorphisms and Wuchereria bancrofti infection status was assessed among individuals whose infection status had been monitored for three decades. Blood samples were collected in 2006 and examined for polymorphisms in the mbl-2 gene and for W. bancrofti-specific circulating filarial antigen (CFA) status. Logistic regression analysis showed a significant association between MBL genotype and CFA status, with low-expression MBL genotype individuals being almost three times more likely to be CFA positive than high-expression MBL genotype individuals (odds ratio [OR] = 2.90). When individuals' filarial infection (microfilaria) status in 1975 was included in the analyses, the gain of new infections between the two examination points was almost 10 times higher among individuals with low than among those with high MBL expression genotype (OR = 9.51). The susceptibility to W. bancrofti infection thus appears to be significantly affected by the MBL expression genotype of the host.
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