ArticleEnvironmental health perspectives2010
Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumors.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 67 citations in OpenAlex.
- Association between long-term ambient air pollution exposure and the risk of breast cancer: a systematic review and meta-analysis.Environmental science and pollution research international · 2021Pooled it
- The relationship between exposure to particulate matter and breast cancer incidence and mortality: A meta-analysis.Medicine · 2019Pooled it
- Environmental tobacco smoke exposure and risk of breast cancer in nonsmoking women. An updated review and meta-analysis.Inhalation toxicology · 2016Pooled it
- Review
- Ambient air pollutants and breast cancer stage in Tehran, Iran.Scientific reports · 2024Article
- Air Quality and Cancer Prevalence Trends across the Sub-Saharan African Regions during 2005-2020.International journal of environmental research and public health · 2022Article
- Correlation of Occupational Exposure to Carcinogenic Polycyclic Aromatic Hydrocarbons (cPAHs) and Blood Levels of p53 and p21 Proteins.Biomolecules · 2022Article
- Genetic Variations in Cytochrome P450 1A1 and 1B1 Genes in a Cohort of Patients from Iraq Diagnosed with Breast Cancer.Breast cancer : basic and clinical research · 2021Article
- DNA damage in cancer development: special implications in viral oncogenesis.American journal of cancer research · 2021Article
- Concentration levels and carcinogenic and mutagenic risks of PMEnvironmental geochemistry and health · 2020Article
- Gene expression profiles for low-dose exposure to diethyl phthalate in rodents and humans: a translational study with implications for breast carcinogenesis.Scientific reports · 2020Article
- Impact of air pollution on breast cancer incidence and mortality: a nationwide analysis in South Korea.Scientific reports · 2020Article
- DNA Damage and Associated DNA Repair Defects in Disease and Premature Aging.American journal of human genetics · 2019Review
- The Photodynamic Properties and the Genotoxicity of Heat-Treated Silicalite-1 Films.Materials (Basel, Switzerland) · 2019Article
- Development of an in Vitro-Based Risk Assessment Framework for Predicting Ambient Particulate Matter-Bound Polycyclic Aromatic Hydrocarbon-Activated Toxicity Pathways.Environmental science & technology · 2017Article
- Long-Term Exposure to Ambient Air Pollution and Incidence of Postmenopausal Breast Cancer in 15 European Cohorts within the ESCAPE Project.Environmental health perspectives · 2017Article
- State of the evidence 2017: an update on the connection between breast cancer and the environment.Environmental health : a global access science source · 2017Review
- Dioxins and related environmental contaminants increase TDP-43 levels.Molecular neurodegeneration · 2017Article
- Polycyclic Aromatic Hydrocarbons In Edible Mushrooms from Niger Delta, Nigeria: Carcinogenic and Non-Carcinogenic Health Risk AssessmentAsian Pacific journal of cancer prevention : APJCP · 2017Article
- The role of the aryl hydrocarbon receptor in the development of cells with the molecular and functional characteristics of cancer stem-like cells.BMC biology · 2016Article
Corrections and comments
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Authors and funding
19 authors at 8 institutions in 3 countries.
Funding
Abstract
backgroundPrevious studies have suggested that polycyclic aromatic hydrocarbons (PAHs) may be associated with breast cancer. However, the carcinogenicity of PAHs on the human breast remains unclear. Certain carcinogens may be associated with specific mutation patterns in the p53 tumor suppressor gene, thereby contributing information about disease etiology.
objectivesWe hypothesized that associations of PAH-related exposures with breast cancer would differ according to tumor p53 mutation status, effect, type, and number.
methodsWe examined this possibility in a population-based case-control study using polytomous logistic regression. As previously reported, 151 p53 mutations among 859 tumors were identified using Surveyor nuclease and confirmed by sequencing.
resultsWe found that participants with p53 mutations were less likely to be exposed to PAHs (assessed by smoking status in 859 cases and 1,556 controls, grilled/smoked meat intake in 822 cases and 1,475 controls, and PAH-DNA adducts in peripheral mononuclear cells in 487 cases and 941 controls) than participants without p53 mutations. For example, active and passive smoking was associated with p53 mutation-negative [odds ratio (OR) = 1.55; 95% confidence interval (CI), 1.11-2.15] but not p53 mutation-positive (OR = 0.77; 95% CI, 0.43-1.38) cancer (ratio of the ORs = 0.50, p < 0.05). However, frameshift mutations, mutation number, G:C-->A:T transitions at CpG sites, and insertions/deletions were consistently elevated among exposed subjects.
conclusionsThese findings suggest that PAHs may be associated with specific breast tumor p53 mutation subgroups rather than with overall p53 mutations and may also be related to breast cancer through mechanisms other than p53 mutation.
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