ArticleEnvironmental health perspectives2010
Effects of diisononyl phthalate on atopic dermatitis in vivo and immunologic responses in vitro.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 61 citations in OpenAlex.
- Relationship between shellfish consumption and urinary phthalate metabolites: Korean National Environmental Health Survey (KoNEHS) cycle 3 (2015-2017).Annals of occupational and environmental medicine · 2023Article
- The Impact of Di-Isononyl Phthalate Exposure on Specialized Epithelial Cells in the Colon.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Biotechnology-based microbial degradation of plastic additives.3 Biotech · 2021Review
- Oral exposure to low dose bisphenol A aggravates allergic airway inflammation in mice.Toxicology reports · 2019Article
- Prenatal Exposure to Phthalates and the Development of Eczema Phenotypes in Male Children: Results from the EDEN Mother-Child Cohort Study.Environmental health perspectives · 2018Article
- Environmental pollution and allergies.Journal of toxicologic pathology · 2017Review
- TRPA1 mediated aggravation of allergic contact dermatitis induced by DINP and regulated by NF-κB activation.Scientific reports · 2017Article
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- Induction of thymic stromal lymphopoietin production by nonanoic acid and exacerbation of allergic inflammation in mice.Allergology international : official journal of the Japanese Society of Allergology · 2013Article
- Engineered silica nanoparticles act as adjuvants to enhance allergic airway disease in mice.Particle and fibre toxicology · 2013Article
- Exposure to low-dose bisphenol A during the juvenile period of development disrupts the immune system and aggravates allergic airway inflammation in mice.International journal of immunopathology and pharmacologyArticle
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDiisononyl phthalate (DINP), a principal plasticizer in many polyvinyl chloride products, has been shown to have an adjuvant effect on immunoglobulin (Ig) production in mice. However, the effects of DINP on allergic diseases have not been fully elucidated.
objectivesIn the present study we investigated the effects of DINP on atopic dermatitis (AD)-like skin lesions induced by Dermatophagoides pteronyssinus (Dp) in atopic-prone NC/Nga mice.
methodsMice were injected intradermally with Dp on their ears and were exposed to DINP (0, 0.15, 1.5, 15, or 150 mg/kg/day) intraperitoneally. We evaluated clinical scores, ear thickening, histologic findings, protein expression of cytokines/chemokines in the ear, and serum levels of Ig and histamine. Furthermore, we investigated the effects of DINP on bone-marrow-derived dendritic cells (BMDCs) or splenocytes in vitro. After exposure to DINP (0-100 microM), cells were evaluated for phenotype and function.
resultsDINP aggravated AD-like skin lesions related to Dp. The aggravation was consistent with eosinophilic inflammation, mast cell degranulation, and thymic stromal lymphopoietin (TSLP) expression in the ear. DINP enhanced the expression of cell surface activation markers on BMDCs and their production of TARC/CCL17 (thymus- and activation-regulated chemokine) and MDC/CCL22 (macrophage-derived chemokine), as well as their capacity to stimulate Dp-specific T-cell proliferation. DINP also enhanced interleukin-4 production and Dp-stimulated proliferation of splenocytes.
conclusionsDINP can aggravate AD-like skin lesions related to Dp. The mechanisms of the aggravation might be mediated, at least partly, through the TSLP-related activation of dendritic cells and by direct or indirect activation of the immune cells.
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