ArticleEnvironmental health perspectives2010
Barrier capacity of human placenta for nanosized materials.
Article in Environmental health perspectives, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06107933 (Developmental Impacts of MicroPLastics Exposure in Early Life), which is not on this map. Cited by 210 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developmental Impacts of MicroPLastics Exposure in Early Life
Who cites it
210 citing papers in PubMed, 8 syntheses or guidelines pooled it.
- Safety and Efficacy of OnabotulinumtoxinA in Pregnancy: A Systematic Review.Aesthetic plastic surgery · 2026Pooled it
- A systematic review of the potential neurotoxicity of micro-and nanoplastics: the known and unknown.Particle and fibre toxicology · 2025Pooled it
- Can Mammalian Reproductive Health Withstand Massive Exposure to Polystyrene Micro- and Nanoplastic Derivatives? A Systematic Review.International journal of molecular sciences · 2024Pooled it
- A Systematic Review of the Placental Translocation of Micro- and Nanoplastics.Current environmental health reports · 2023Pooled it
- A Systematic Review on the Hazard Assessment of Amorphous Silica Based on the Literature From 2013 to 2018.Frontiers in public health · 2022Pooled it
- Adverse Birth Outcomes Related to NOInternational journal of environmental research and public health · 2020Pooled it
- Translocation of (ultra)fine particles and nanoparticles across the placenta; a systematic review on the evidence of in vitro, ex vivo, and in vivo studies.Particle and fibre toxicology · 2020Pooled it
- Outdoor Air Pollution and Brain Structure and Function From Across Childhood to Young Adulthood: A Methodological Review of Brain MRI Studies.Frontiers in public health · 2019Pooled it
- Human Exposure to Micro- and Nanoplastics:Environment & health (Washington, D.C.) · 2026Review
- New approach methodologies in nanomedicine: bridging the gap betweenChemical Society reviews · 2026Review
- Polystyrene nanoplastics disrupt mouse placenta development in a sex-dependent manner.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- Exploring the Potential Impact of Nanoparticles on Fetal Development: An Updated Review.Medicina (Kaunas, Lithuania) · 2026Review
- Article
- Review
- Polystyrene Nanoplastics Disrupt Mouse Placenta Development in a Sex-Dependent Manner.bioRxiv : the preprint server for biology · 2026Article
- Microplastics in Female Reproductive and Pregnancy Organs: A Systematic Review.Life (Basel, Switzerland) · 2026Review
- Health Risks of Prenatal and Early-Life Microplastics Exposure: A Comprehensive Review.Environment & health (Washington, D.C.) · 2026Review
- A Review of the Increasing Impact and Effects of Air Pollution Throughout Life and Before Birth.Medical science monitor : international medical journal of experimental and clinical research · 2026Review
- Microplastics and nanoplastics in human health: a comprehensive review of exposure pathways, cellular mechanisms, and toxicological implications.Archives of toxicology · 2026Review
- A comparative biodistribution and toxicity study of single and multi-component nanomaterials: NMs: TiOParticle and fibre toxicology · 2026Article
150 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHumans have been exposed to fine and ultrafine particles throughout their history. Since the Industrial Revolution, sources, doses, and types of nanoparticles have changed dramatically. In the last decade, the rapidly developing field of nanotechnology has led to an increase of engineered nanoparticles with novel physical and chemical properties. Regardless of whether this exposure is unintended or not, a careful assessment of possible adverse effects is needed. A large number of projects have been carried out to assess the consequences of combustion-derived or engineered nanoparticle exposure on human health. In recent years there has been a growing concern about the possible health influence of exposure to air pollutants during pregnancy, hence an implicit concern about potential risk for nanoparticle exposure in utero. Previous work has not addressed the question of whether nanoparticles may cross the placenta.
objectiveIn this study we investigated whether particles can cross the placental barrier and affect the fetus.
methodsWe used the ex vivo human placental perfusion model to investigate whether nanoparticles can cross this barrier and whether this process is size dependent. Fluorescently labeled polystyrene beads with diameters of 50, 80, 240, and 500 nm were chosen as model particles.
resultsWe showed that fluorescent polystyrene particles with diameter up to 240 nm were taken up by the placenta and were able to cross the placental barrier without affecting the viability of the placental explant.
conclusionsThe findings suggest that nanomaterials have the potential for transplacental transfer and underscore the need for further nanotoxicologic studies on this important organ system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.