ArticleJournal of molecular biology2010
Comparative genomic analysis of 60 Mycobacteriophage genomes: genome clustering, gene acquisition, and gene size.
Article in Journal of molecular biology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 212 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
212 citing papers in PubMed, 307 citations in OpenAlex.
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- Complete genome sequence of Jobypre, an L3 subcluster mycobacteriophage isolated from marsh soil in Charleston, South Carolina.Microbiology resource announcements · 2025Article
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- Complete genome sequence of mycobacteriophage Hashim76, a B13 subcluster phage, from Hanahan, South Carolina.Microbiology resource announcements · 2025Article
- CRISPRi-mediated repression of threeJournal of bacteriology · 2025Article
- Comparative Genomic Analysis of 66 Bacteriophages Infecting Morganella morganii Strains.Current microbiology · 2025Article
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- Complete Genome Sequences of Mycobacteriophages Balomoji, Crumble, Frederick, ShowerHandel, TinyTimmy and Zabiza.microPublication biology · 2025Article
- Nine Cluster E mycobacteriophages isolated from soil.Microbiology resource announcements · 2024Article
- Characterization of mycobacteriophage Adephagia cytotoxic proteins.G3 (Bethesda, Md.) · 2024Article
- Complete genome sequence ofMicrobiology resource announcements · 2024Article
- A Bioinformatic Ecosystem for Bacteriophage Genomics: PhaMMSeqs, Phamerator, pdm_utils, PhagesDB, DEPhT, and PhamClust.Viruses · 2024Review
- Introducing Casbah, Kronus, and MmasiCarm, Members of the Mycobacteriophage Subcluster B3.PHAGE (New Rochelle, N.Y.) · 2024Article
- Bioinformatic Approaches for Comparative Analysis of Viruses.Methods in molecular biology (Clifton, N.J.) · 2024Article
152 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
27 authors at 3 institutions in 1 country.
Funding
Abstract
Mycobacteriophages are viruses that infect mycobacterial hosts. Expansion of a collection of sequenced phage genomes to a total of 60-all infecting a common bacterial host-provides further insight into their diversity and evolution. Of the 60 phage genomes, 55 can be grouped into nine clusters according to their nucleotide sequence similarities, 5 of which can be further divided into subclusters; 5 genomes do not cluster with other phages. The sequence diversity between genomes within a cluster varies greatly; for example, the 6 genomes in Cluster D share more than 97.5% average nucleotide similarity with one another. In contrast, similarity between the 2 genomes in Cluster I is barely detectable by diagonal plot analysis. In total, 6858 predicted open-reading frames have been grouped into 1523 phamilies (phams) of related sequences, 46% of which possess only a single member. Only 18.8% of the phams have sequence similarity to non-mycobacteriophage database entries, and fewer than 10% of all phams can be assigned functions based on database searching or synteny. Genome clustering facilitates the identification of genes that are in greatest genetic flux and are more likely to have been exchanged horizontally in relatively recent evolutionary time. Although mycobacteriophage genes exhibit a smaller average size than genes of their host (205 residues compared with 315), phage genes in higher flux average only 100 amino acids, suggesting that the primary units of genetic exchange correspond to single protein domains.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.