ArticleMolecular cell2009
Nucleosome remodeling by hMSH2-hMSH6.
Article in Molecular cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed.
- Chromatin dynamics and cellular energy homeostasis.Journal of biochemistry · 2026Review
- Article
- ARID1A regulates histone octamer transfer activity of human canonical BAF complex.Nucleic acids research · 2025Article
- MutS functions as a clamp loader by positioning MutL on the DNA during mismatch repair.Nature communications · 2022Article
- Chromatin remodeling and mismatch repair: Access and excision.DNA repair · 2020Review
- Nucleosome DNA unwrapping does not affect prototype foamy virus integration efficiency or site selection.PloS one · 2019Article
- The properties of Msh2-Msh6 ATP binding mutants suggest a signal amplification mechanism in DNA mismatch repair.The Journal of biological chemistry · 2018Article
- Coordinating Multi-Protein Mismatch Repair by Managing Diffusion Mechanics on the DNA.Journal of molecular biology · 2018Review
- MutS homolog sliding clamps shield the DNA from binding proteins.The Journal of biological chemistry · 2018Article
- Identification of Exo1-Msh2 interaction motifs in DNA mismatch repair and new Msh2-binding partners.Nature structural & molecular biology · 2018Article
- Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1.Genes & development · 2018Article
- Epigenetic Enhancement of the Post-replicative DNA Mismatch Repair of Mammalian Genomes by a Hemi-Scientific reports · 2016Article
- Dynamic DNA binding licenses a repair factor to bypass roadblocks in search of DNA lesions.Nature communications · 2016Article
- A personal historical view of DNA mismatch repair with an emphasis on eukaryotic DNA mismatch repair.DNA repair · 2016Review
- Regulation of mismatch repair by histone code and posttranslational modifications in eukaryotic cells.DNA repair · 2016Review
- Mutations that prevent or mimic persistent post-translational modifications of the histone H3 globular domain cause lethality and growth defects in Drosophila.Epigenetics & chromatin · 2016Article
- Histone Acetylation near the Nucleosome Dyad Axis Enhances Nucleosome Disassembly by RSC and SWI/SNF.Molecular and cellular biology · 2015Article
- Mismatch repair.The Journal of biological chemistry · 2015Review
- LncRNA HOTAIR promotes human liver cancer stem cell malignant growth through downregulation of SETD2.Oncotarget · 2015Article
- Generation of a synthetic GlcNAcylated nucleosome reveals regulation of stability by H2A-Thr101 GlcNAcylation.Nature communications · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
DNA nucleotide mismatches and lesions arise on chromosomes that are a complex assortment of protein and DNA (chromatin). The fundamental unit of chromatin is a nucleosome that contains approximately 146 bp DNA wrapped around an H2A, H2B, H3, and H4 histone octamer. We demonstrate that the mismatch recognition heterodimer hMSH2-hMSH6 disassembles a nucleosome. Disassembly requires a mismatch that provokes the formation of hMSH2-hMSH6 hydrolysis-independent sliding clamps, which translocate along the DNA to the nucleosome. The rate of disassembly is enhanced by actual or mimicked acetylation of histone H3 within the nucleosome entry-exit and dyad axis that occurs during replication and repair in vivo and reduces DNA-octamer affinity in vitro. Our results support a passive mechanism for chromatin remodeling whereby hMSH2-hMSH6 sliding clamps trap localized fluctuations in nucleosome positioning and/or wrapping that ultimately leads to disassembly, and highlight unanticipated strengths of the Molecular Switch Model for mismatch repair (MMR).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.