ArticleChemistry & biology2009
Telomeres and telomerase: from discovery to clinical trials.
Article in Chemistry & biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- The potential role of PAX5 and PAX8 in regulating telomerase activity: a narrative mini-review.Molecular biology reports · 2025Review
- Telomere Biology Disorder: A Focus on Gastrointestinal and Hepatic Manifestations.Current hematologic malignancy reports · 2024Review
- Review
- Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age.Aging medicine (Milton (N.S.W)) · 2022Review
- Test Strip Platform Spin-Off for Telomerase Activity Detection: Development of an Electrochemical Biosensor.ACS omega · 2022Article
- The intervention on aging system: A classification model, the requirement for five novel categories.Aging medicine (Milton (N.S.W)) · 2022Review
- The tarnished silver spoon? Trade-off between prenatal growth and telomere length in wild boar.Journal of evolutionary biology · 2022Article
- In perspective: An update on telomere targeting in cancer.Molecular carcinogenesis · 2019Review
- Catalysis-dependent inactivation of human telomerase and its reactivation by intracellular telomerase-activating factors (iTAFs).The Journal of biological chemistry · 2019Article
- Ethenesulfonyl fluoride derivatives as telomerase inhibitors: structure-based design, SAR, and anticancer evaluation in vitro.Journal of enzyme inhibition and medicinal chemistry · 2018Article
- Chemistry, mechanism and clinical status of antisense oligonucleotides and duplex RNAs.Nucleic acids research · 2018Review
- Aptamer Bioinformatics.International journal of molecular sciences · 2017Review
- Epstein-Barr virus and telomerase: from cell immortalization to therapy.Infectious agents and cancer · 2014Article
- An improved model for the hTERT promoter quadruplex.PloS one · 2014Article
- Article
- Old age as a privilege of the "selfish ones".Aging and disease · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Telomeres are the ends of linear chromosomes. They cannot be fully replicated by standard polymerases and are maintained by the ribonucleoprotein telomerase. Telomeres and telomerase stand at a junction of critical processes underlying chromosome integrity, cancer, and aging, and their importance was recognized by the 2009 Nobel Prize in Physiology or Medicine to Elizabeth Blackburn, Jack Szostak, and Carol Greider. Where will the field go now? What are the prospects for antitelomerase agents as drugs? Nearly 30 years after Szostak and Blackburn's pioneering manuscript on telomere ends, the challenges of discovery remain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.