Evidence map›Paper›PMID 20064383›Full record

ArticleNeuron2009

A molecular sensor for the baroreceptor reflex?

Edwin W McCleskey

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Piezo ion channels: long-sought-after mechanosensors mediating hypertension and hypertensive nephropathy.Hypertension research : official journal of the Japanese Society of Hypertension · 2024
    Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Edwin W McCleskeyHoward Hughes Medical Institute, Chevy Chase, MD 20815, USA. mccleskeye@hhmi.org
Howard Hughes Medical Institute · US

Funding

Howard Hughes Medical Institute
6 · The paper itself

Abstract

The reflex that provides rapid neural control of blood pressure is triggered by an unknown molecular pressure sensor. ASIC2, an ion channel in a family that includes a mechanosensor from C. elegans, is shown by Lu et al. in this issue of Neuron to be critical for this reflex in mice, perhaps because ASIC2 is the elusive pressure sensor.

Indexed as

Cardiovascular Physiological PhenomenaAcid Sensing Ion ChannelsAnimalsAnimals, Genetically ModifiedAutonomic Nervous SystemBaroreflexBlood PressureDisease Models, AnimalHumansMechanotransduction, CellularMiceNerve Tissue ProteinsPressoreceptorsPrimary DysautonomiasSensory Receptor CellsSodium ChannelsAcid Sensing Ion ChannelsASIC2 protein, mouseNerve Tissue ProteinsSodium Channels

Identifiers

PMID20064383
OpenAlexW2004199409

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.