ArticleBMC infectious diseases2010
Modelling imperfect adherence to HIV induction therapy.
Article in BMC infectious diseases, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of treatment fatigue among HIV-infected patients prescribed antiretroviral therapy.Psychology, health & medicine · 2015Pooled it
- Integration of Patient Reported Outcomes Data among People with HIV in Washington, DC: A sub-cohort of the DC Cohort Longitudinal Study.Journal of public health (Berlin, Germany) · 2025Article
- Genetic and non-genetic factors influencing efavirenz population pharmacokinetics among human immunodeficiency virus-1-infected children in Ethiopia.CPT: pharmacometrics & systems pharmacology · 2023Article
- Global Dynamics of SARS-CoV-2 Infection with Antibody Response and the Impact of Impulsive Drug Therapy.Vaccines · 2022Article
- A qualitative study of antiretroviral therapy adherence interruptions among young Latino men who have sex with men with HIV: Project D.A.I.L.Y.AIDS care · 2021Article
- A Model for SARS-CoV-2 Infection with Treatment.Computational and mathematical methods in medicine · 2020Article
- An update on the Barriers to Adherence and a Definition of Self-Report Non-adherence Given Advancements in Antiretroviral Therapy (ART).AIDS and behavior · 2018Article
- Human immunodeficiency virus/acquired immune deficiency syndrome: Using drug from mathematical perceptive.World journal of virology · 2015Review
- Identifying the Conditions Under Which Antibodies Protect Against Infection by Equine Infectious Anemia Virus.Vaccines · 2014Article
- Modeling antiretroviral drug responses for HIV-1 infected patients using differential equation models.Advanced drug delivery reviews · 2013Review
- Assessing the impact of adherence to anti-retroviral therapy on treatment failure and resistance evolution in HIV.Journal of the Royal Society, Interface · 2012Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInduction-maintenance therapy is a treatment regime where patients are prescribed an intense course of treatment for a short period of time (the induction phase), followed by a simplified long-term regimen (maintenance). Since induction therapy has a significantly higher chance of pill fatigue than maintenance therapy, patients might take drug holidays during this period. Without guidance, patients who choose to stop therapy will each be making individual decisions, with no scientific basis.
methodsWe use mathematical modelling to investigate the effect of imperfect adherence during the inductive phase. We address the following research questions: 1. Can we theoretically determine the maximal length of a possible drug holiday and the minimal number of doses that must subsequently be taken while still avoiding resistance? 2. How many drug holidays can be taken during the induction phase?
resultsFor a 180 day therapeutic program, a patient can take several drug holidays, but then has to follow each drug holiday with a strict, but fairly straightforward, drug-taking regimen. Since the results are dependent upon the drug regimen, we calculated the length and number of drug holidays for all fifteen protease-sparing triple-drug cocktails that have been approved by the US Food and Drug Administration.
conclusionsInduction therapy with partial adherence is tolerable, but the outcome depends on the drug cocktail. Our theoretical predictions are in line with recent results from pilot studies of short-cycle treatment interruption strategies and may be useful in guiding the design of future clinical trials.
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