ArticleBMC immunology2010
AUF1 is involved in splenic follicular B cell maintenance.
Article in BMC immunology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 84 citations in OpenAlex.
- HGF, HNRPD, and sFLT1 Interfere with the Induction of VEGF in Patients with Severe Psoriasis.Current molecular medicine · 2025Article
- Crosstalk between RNA-Binding Proteins and Immune Microenvironment Revealed Two RBP Regulatory Patterns with Distinct Immunophenotypes in Periodontitis.Journal of immunology research · 2021Article
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- Uncovering the Role of RNA-Binding Proteins in Gene Expression in the Immune System.Frontiers in immunology · 2018Review
- Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE-/- Mice.Arteriosclerosis, thrombosis, and vascular biology · 2016Article
- RNA binding proteins as regulators of immune cell biology.Clinical and experimental immunology · 2016Review
- The RNA-binding protein HuR is essential for the B cell antibody response.Nature immunology · 2015Article
- Deletion of AU-rich elements within the Bcl2 3'UTR reduces protein expression and B cell survival in vivo.PloS one · 2015Article
- RNA-binding protein AUF1 promotes myogenesis by regulating MEF2C expression levels.Molecular and cellular biology · 2014Article
- Article
- Hsp27 and F-box protein β-TrCP promote degradation of mRNA decay factor AUF1.Molecular and cellular biology · 2013Article
- Post-transcriptional regulatory networks in immunity.Immunological reviews · 2013Review
- Exploring the RNA world in hematopoietic cells through the lens of RNA-binding proteins.Immunological reviews · 2013Review
- Combinatorial mRNA binding by AUF1 and Argonaute 2 controls decay of selected target mRNAs.Nucleic acids research · 2013Article
- AUF1/hnRNP D represses expression of VEGF in macrophages.Molecular biology of the cell · 2012Article
- AUF1 and HuR: possible implications of mRNA stability in thyroid function and disorders.Thyroid research · 2011Article
- Post-transcriptional control of gene expression by AUF1: mechanisms, physiological targets, and regulation.Biochimica et biophysica actaReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe adenosine/uridine-rich element (ARE)-binding protein AUF1 functions to regulate the inflammatory response through the targeted degradation of cytokine and other mRNAs that contain specific AREs in their 3' noncoding region (3' NCR). To investigate the role of AUF1 in the immune system, we characterized the lymphoid compartments of AUF1-deficient mice.
resultsMice lacking AUF1 exhibit an altered proportion and size of splenic B cell subsets. We show prominent apoptosis in splenic B cell follicles and reduced expression of Bcl-2, A1, and Bcl-XL correlate with increased turnover and significant reduction in the number and proportion of splenic FO B cells in AUF1-deficient mice. In addition, AUF1-deficient mice exhibit a sharp decrease in splenic size and lymphocyte cellularity. Bone marrow transfer studies demonstrate that AUF1 deficiency induces cell-autonomous defects in mature B cell subsets but not in the overall number of splenocytes. Reconstitution of irradiated adult AUF1-deficient mice with wild-type bone marrow restores the proportion of FO and marginal zone (MZ) B cells, but does not rescue the decrease in the number of splenocytes. Functionally, AUF1-deficient mice mount an attenuated response to T cell-independent (TI) antigen, which correlates with impaired MZ B cell function.
conclusionThese data indicate that AUF1 is important in the maintenance of splenic FO B cells and adequate humoral immune responses.
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