ArticleBMC microbiology2010
The capsule of Porphyromonas gingivalis reduces the immune response of human gingival fibroblasts.
Article in BMC microbiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 110 citations in OpenAlex.
- Host insulin resistance caused byFrontiers in cellular and infection microbiology · 2023Pooled it
- Evaluation of adjunctive systemic doxycycline with non-surgical periodontal therapy within type 2 diabetic patients.Saudi medical journal · 2014Trial
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- Association between dysbiotic perio-pathogens and inflammatory initiators and mediators in COVID-19 patients with diabetes.Heliyon · 2024Article
- Human Coronary Artery Endothelial Cell Response toMicroorganisms · 2024Article
- Isolation, characterization, and fibroblast uptake of bacterial extracellular vesicles from Porphyromonas gingivalis strains.MicrobiologyOpen · 2023Article
- Local and Systemic Effects ofMicroorganisms · 2023Review
- Article
- Porphyromonas gingivalis Virulence Factors and Clinical Significance in Periodontal Disease and Coronary Artery DiseasesPathogens (Basel, Switzerland) · 2022Review
- HowMaterials (Basel, Switzerland) · 2022Review
- Porphyromonas gingivalis outside the oral cavity.Odontology · 2022Review
- Gemella haemolysans inhibits the growth of the periodontal pathogen Porphyromonas gingivalis.Scientific reports · 2021Article
- Microbial Lipid A Remodeling Controls Cross-Presentation Efficiency and CD8 T Cell Priming by Modulating Dendritic Cell Function.Infection and immunity · 2021Article
- Antimicrobial Mechanisms of Leucocyte- and Platelet Rich Fibrin Exudate Against PlanktonicFrontiers in cellular and infection microbiology · 2021Article
- Epstein-Barr Virus-Oral Bacterial Link in the Development of Oral Squamous Cell Carcinoma.Pathogens (Basel, Switzerland) · 2020Review
- Defining principles that influence antimicrobial peptide activity against capsulatedProceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPeriodontitis is a bacterial infection of the periodontal tissues. The Gram-negative anaerobic bacterium Porphyromonas gingivalis is considered a major causative agent. One of the virulence factors of P. gingivalis is capsular polysaccharide (CPS). Non-encapsulated strains have been shown to be less virulent in mouse models than encapsulated strains.
resultsTo examine the role of the CPS in host-pathogen interactions we constructed an insertional isogenic P. gingivalis knockout in the epimerase-coding gene epsC that is located at the end of the CPS biosynthesis locus. This mutant was subsequently shown to be non-encapsulated. K1 capsule biosynthesis could be restored by in trans expression of an intact epsC gene. We used the epsC mutant, the W83 wild type strain and the complemented mutant to challenge human gingival fibroblasts to examine the immune response by quantification of IL-1beta, IL-6 and IL-8 transcription levels. For each of the cytokines significantly higher expression levels were found when fibroblasts were challenged with the epsC mutant compared to those challenged with the W83 wild type, ranging from two times higher for IL-1beta to five times higher for IL-8.
conclusionsThese experiments provide the first evidence that P. gingivalis CPS acts as an interface between the pathogen and the host that may reduce the host's pro-inflammatory immune response. The higher virulence of encapsulated strains may be caused by this phenomenon which enables the bacteria to evade the immune system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.